Synthesis of the C11-C29 fragment of amphidinolide F

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Overview

authors

• Shotwell, J. B.
• Roush, William

publication date

• October 2004

journal

• Organic Letters  Journal

abstract

• [reaction: see text] An efficient synthesis of the C(11)-C(29) fragment 31 of amphidinolide F has been accomplished via a diastereoselective [3 + 2]-annulation reaction of allylsilane 5 and ethyl glyoxylate to prepare the key tetrahydrofuran 15 and a highly stereoselective methyl ketone aldol reaction to generate the C(11)-C(16) segment.

subject areas

• Heterocyclic Compounds
• Macrolides

Identity

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol048381z

PubMed ID

• 15469369

Additional Document Info

start page

• 3865

end page

• 3868

volume

• 6

issue

• 21