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Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase

Academic Article
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Overview

authors

  • Wakasugi, K.
  • Slike, B. M.
  • Hood, J.
  • Ewalt, K. L.
  • Cheresh, D. A.
  • Schimmel, Paul

publication date

  • 2002

journal

  • Journal of Biological Chemistry  Journal

abstract

  • The first step of protein synthesis is catalyzed by aminoacyl-tRNA synthetases. In addition, certain mammalian tRNA synthetases link protein synthesis to cytokine signaling pathways. In particular, human tyrosyl-tRNA synthetase (TyrRS) can be split by proteolysis into two fragments having distinct cytokine activities. One of the TyrRS fragments (mini TyrRS) contains features identical to those in CXC chemokines (like interleukin-8) that also act as angiogenic factors. Here mini TyrRS (but not full-length TyrRS) is shown to stimulate chemotaxis of endothelial cells in vitro and stimulate angiogenesis in each of two in vivo animal models. The angiogenic activity of mini TyrRS can be opposed by anti-angiogenic chemokines like IP-10. Thus, a biological fragment of human tyrosyl-tRNA synthetase links protein synthesis to regulation of angiogenesis.

subject areas

  • Allantoin
  • Animals
  • Cells, Cultured
  • Chemotaxis
  • Chick Embryo
  • Chorion
  • Endothelium, Vascular
  • Humans
  • Neovascularization, Physiologic
  • Recombinant Proteins
  • Tyrosine-tRNA Ligase
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.C200126200

PubMed ID

  • 11956181
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Additional Document Info

start page

  • 20124

end page

  • 20126

volume

  • 277

issue

  • 23

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