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The ribosome filter hypothesis

Academic Article
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Overview

authors

  • Mauro, Vincent
  • Edelman, Gerald

publication date

  • 2002

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • A variety of posttranscriptional mechanisms affects the processing, subcellular localization, and translation of messenger RNAs (mRNAs). Translational control appears to occur primarily at the initiation rather than the elongation stage. It has been suggested that translation is mediated largely by means of a cap-binding/scanning mechanism. On the basis of recent findings, we propose here that differential binding of particular mRNAs to eukaryotic 40S ribosomal subunits before translation may also selectively affect rates of polypeptide chain production. In this view, ribosomal subunits themselves are considered to be regulatory elements or filters that mediate interactions between particular mRNAs and components of the translation machinery. Differences in these interactions affect how efficiently individual mRNAs compete for ribosomal subunits. These competitive interactions would depend in part on the complementarity between sequences in mRNA and rRNA, as well as on structural differences among ribosomes in different cell types. By these means, translation may either be enhanced through increased recruitment of ribosomes or inhibited through strong interactions that sequester mRNAs. We propose that ribosomal filters may be important in cell differentiation and describe experimental tests for the filter hypothesis.

subject areas

  • Models, Biological
  • Peptide Chain Initiation, Translational
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger
  • RNA, Ribosomal
  • Ribosomal Proteins
  • Ribosomes
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Identity

PubMed Central ID

  • PMC129393

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.192442499

PubMed ID

  • 12221294
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Additional Document Info

start page

  • 12031

end page

  • 12036

volume

  • 99

issue

  • 19

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