Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Essential role of stromally induced hedgehog signaling in B-cell malignancies

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Grbic, Jovana J, Ph.D. in Chemistry, Scripps Research 2002 - 2007

authors

  • Dierks, C.
  • Grbic, Jovana J
  • Zirlik, K.
  • Beigi, R.
  • Englund, N. P.
  • Guo, G. R.
  • Veelken, H.
  • Engelhardt, M.
  • Mertelsmann, R.
  • Kelleher, J. F.
  • Schultz, Peter
  • Warmuth, M.

publication date

  • August 2007

journal

  • Nature Medicine  Journal

abstract

  • Interaction of cancer cells with their microenvironment generated by stromal cells is essential for tumor cell survival and influences the localization of tumor growth. Here we demonstrate that hedgehog ligands secreted by bone-marrow, nodal and splenic stromal cells function as survival factors for malignant lymphoma and plasmacytoma cells derived from transgenic Emu-Myc mice or isolated from humans with these malignancies. Hedgehog pathway inhibition in lymphomas induced apoptosis through downregulation of Bcl2, but was independent of p53 or Bmi1 expression. Blockage of hedgehog signaling in vivo inhibited expansion of mouse lymphoma cells in a syngeneic mouse model and reduced tumor mass in mice with fully developed disease. Our data indicate that stromally induced hedgehog signaling may provide an important survival signal for B- and plasma-cell malignancies in vitro and in vivo. Disruption of this interaction by hedgehog pathway inhibition could provide a new strategy in lymphoma and multiple myeloma therapy.

subject areas

  • Animals
  • Cell Line
  • Cell Survival
  • Hedgehog Proteins
  • Humans
  • Ligands
  • Lymphoma, B-Cell
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Oncogene Proteins
  • Phenotype
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Signal Transduction
  • Skin Neoplasms
  • Stromal Cells
  • Survival Rate
  • Trans-Activators
  • Veratrum Alkaloids
  • Xenograft Model Antitumor Assays
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm1614

PubMed ID

  • 17632527
scroll to property group menus

Additional Document Info

start page

  • 944

end page

  • 951

volume

  • 13

issue

  • 8

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support