recent publications

• academic article

  • Natividad, L. A., Buczynski, M. W., Parsons, L. H., Torres, O. V., O'Dell, L. E. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal Journal of Neurochemistry  2012 123:578-588  DOI:10.1111/j.1471-4159.2012.07926.x  PMID:22905672  PMCID:PMC3472122
  • Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis Journal of Neuroscience  2009 29:5389-5401  DOI:10.1523/jneurosci.5129-08.2009  PMID:19403807  PMCID:PMC2938175
  • Richardson, H. N., Lee, S. Y., O'Dell, L. E., Koob, G. F., Rivier, C. L. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state European Journal of Neuroscience  2008 28:1641-1653  DOI:10.1111/j.1460-9568.2008.06455.x  PMID:18979677  PMCID:PMC2748838
  • Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience  2008 28:5762-5771  DOI:10.1523/jneurosci.0575-08.2008  PMID:18509038  PMCID:PMC2493536
  • Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F. Crf1 receptor antagonists attenuate escalated cocaine self-administration in rats Psychopharmacology  2008 196:473-482  DOI:10.1007/s00213-007-0983-9  PMID:17965976  PMCID:PMC2769571
  • O'Dell, L. E., Koob, G. F. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration Pharmacology, Biochemistry and Behavior  2007 86:346-353  DOI:10.1016/j.pbb.2007.01.004  PMID:17292952  PMCID:PMC2386418
  • Frantz, K. J., O'Dell, L. E., Parsons, L. H. Behavioral and neurochemical responses to cocaine in periadolescent and adult rats Neuropsychopharmacology  2007 32:625-637  DOI:10.1038/sj.npp.1301130  PMID:16794567
  • George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats Proceedings of the National Academy of Sciences of the United States of America  2007 104:17198-17203  DOI:10.1073/pnas.0707585104  PMID:17921249  PMCID:PMC2040467
  • O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats Journal of Pharmacology and Experimental Therapeutics  2007 320:180-193  DOI:10.1124/jpet.106.105270  PMID:17050784
  • Thorsell, A., Repunte-Canonigo, V., O'Dell, L. E., Chen, S. A., King, A. R., Lekic, D., Koob, G. F., Sanna, P. P. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats Brain  2007 130:1330-1337  DOI:10.1093/brain/awm033  PMID:17405766  PMCID:PMC2749684
  • O'Dell, L. E., Manzardo, A. M., Polis, I., Stouffer, D. G., Parsons, L. H. Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration Journal of Neurochemistry  2006 99:1363-1376  DOI:10.1111/j.1471-4159.2006.04163.x  PMID:17074068
  • Funk, C. K., O'Dell, L. E., Crawford, E. F., Koob, G. F. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats Journal of Neuroscience  2006 26:11324-11332  DOI:10.1523/jneurosci.3096-06.2006  PMID:17079660
  • O'Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., Markou, A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction Psychopharmacology  2006 186:612-619  DOI:10.1007/s00213-006-0383-6  PMID:16598454
  • Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F. Unlimited access to heroin self-administration: Independent motivational markers of opiate dependence Neuropsychopharmacology  2006 31:2692-2707  DOI:10.1038/sj.npp.1301008  PMID:16452
  • O'Dell, L. E., Purdy, R. H., Covey, D. F., Richardson, H. F., Roberto, M., Koob, G. F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats Pharmacology, Biochemistry and Behavior  2005 81:543-550  DOI:10.1016/j.pbb.2005.03.020  PMID:15950269
  • Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research  2005 29:185-195  DOI:10.1097/01.alc.0000153544.83656.3c  PMID:15714042
  • O'Dell, L. E., Roberts, A. J., Smith, R. T., Koob, G. F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcoholism-Clinical and Experimental Research  2004 28:1676-1682  DOI:10.1097/01.alc.0000145781.11923.4e  PMID:15547454
  • O'Dell, L. E., Alomary, A. A., Vallee, M., Koob, G. F., Fitzgerald, R. L., Purdy, R. H. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats European Journal of Pharmacology  2004 484:241-247  DOI:10.1016/j.ejphar.2003.11.031  PMID:14744609
  • Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews  2004 27:739-749  DOI:10.1016/j.neubiorev.2003.11.007  PMID:15019424
  • O'Dell, L. E., Parsons, L. H. Serotonin(1B) receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels Journal of Pharmacology and Experimental Therapeutics  2004 311:711-719  DOI:10.1124/jpet.104.069278  PMID:15226384
  • Alomary, A. A., Vallee, M., O'Dell, L. E., Koob, G. F., Purdy, R. H., Fitzgerald, R. L. Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain Alcoholism-Clinical and Experimental Research  2003 27:38-43  DOI:10.1097/01.alc.0000047304.28550.4f  PMID:12544003
  • Rocha, B. A., Goulding, E. H., O'Dell, L. E., Mead, A. N., Coufal, N. G., Parsons, L. H., Tecott, L. H. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice Journal of Neuroscience  2002 22:10039-10045  PMID:12427861