Diastereoselective dieckmann condensation suitable for introduction of the duocarmycin A C6 center - development of a divergent strategy for the total synthesis of duocarmycins A and SA

Academic Article
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publication date

  • 1995

abstract

  • The development of a divergent approach to the introduction of the C-ring of the duocarmycin A and SA alkylation subunits is detailed and includes the development of a diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center with control of its relative and natural R absolute configuration.