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Differential effects of morphine, dpdpe, and u-50488 on apomorphine-induced climbing behavior in mu-opioid receptor knockout mice

Academic Article
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Overview

authors

  • Jang, Choon-Gon
  • Lee, S. Y.
  • Park, Y.
  • Ma, T. G.
  • Loh, H. H.
  • Ho, I. K.

publication date

  • October 2001

journal

  • Molecular Brain Research  Journal

abstract

  • The present study examined the hypothesis whether the opioid receptors (mu, delta, and kappa) contribute to a behavioral dopaminergic activation produced by dopamine receptor agonist, apomorphine, by comparing responses in wild type and mu-opioid receptor knockout mice. The data suggest that expression of mu-opioid receptors plays an important role in the enhancement of climbing behavior induced by apomorphine. Compared to wild type mice, a response in the dopaminergic behavior by treatment with delta-receptor agonist, DPDPE, is more sensitive to the mice lacking mu-opioid receptor. Treatment with kappa-receptor agonist, U-50488, is potentiated the apomorphine-induced climbing behavior in wild type and mu-opioid receptor knockout mice. These responses may be independent of that through mu-opioid receptors. Therefore, the our results show that dopaminergic activation measured by climbing behavior in mu-opioid receptors knockout mice are differently regulated by mu-, delta-, and kappa-opioid receptor agonists.

subject areas

  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Analgesics, Non-Narcotic
  • Analgesics, Opioid
  • Animals
  • Apomorphine
  • Dopamine Agonists
  • Enkephalin, D-Penicillamine (2,5)-
  • Female
  • Male
  • Mice
  • Mice, Knockout
  • Morphine
  • Motor Activity
  • Receptors, Opioid, mu
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Research

keywords

  • DPDPE
  • U-50488
  • climbing behavior
  • morphine
  • mu-opioid receptor knockout mice
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Identity

International Standard Serial Number (ISSN)

  • 0169-328X

Digital Object Identifier (DOI)

  • 10.1016/s0169-328x(01)00227-3

PubMed ID

  • 11597780
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Additional Document Info

start page

  • 197

end page

  • 199

volume

  • 94

issue

  • 1-2

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