related to degree

• Xie, Jianming, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

• Xie, Jianming
• Schultz, Peter

publication date

• October 2006

journal

• Nature Reviews Molecular Cell Biology  Journal

abstract

• Recently, a method to encode unnatural amino acids with diverse physicochemical and biological properties genetically in bacteria, yeast and mammalian cells was developed. Over 30 unnatural amino acids have been co-translationally incorporated into proteins with high fidelity and efficiency using a unique codon and corresponding transfer-RNA:aminoacyl-tRNA-synthetase pair. This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties.

subject areas

• Amino Acids
• Amino Acyl-tRNA Synthetases
• Base Sequence
• Codon
• Escherichia coli
• Genetic Code
• In Vitro Techniques
• Molecular Sequence Data
• Mutagenesis, Site-Directed
• Mutation
• Protein Biosynthesis
• Protein Engineering
• Proteins
• RNA, Transfer

International Standard Serial Number (ISSN)

• 1471-0072

Digital Object Identifier (DOI)

• 10.1038/nrm2005

PubMed ID

• 16926858

start page

• 775

end page

• 782

volume

• 7

issue

• 10