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A chemical toolkit for proteins: an expanded genetic code

Academic Article
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Overview

related to degree

  • Xie, Jianming, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Xie, Jianming
  • Schultz, Peter

publication date

  • October 2006

journal

  • Nature Reviews Molecular Cell Biology  Journal

abstract

  • Recently, a method to encode unnatural amino acids with diverse physicochemical and biological properties genetically in bacteria, yeast and mammalian cells was developed. Over 30 unnatural amino acids have been co-translationally incorporated into proteins with high fidelity and efficiency using a unique codon and corresponding transfer-RNA:aminoacyl-tRNA-synthetase pair. This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties.

subject areas

  • Amino Acids
  • Amino Acyl-tRNA Synthetases
  • Base Sequence
  • Codon
  • Escherichia coli
  • Genetic Code
  • In Vitro Techniques
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Mutation
  • Protein Biosynthesis
  • Protein Engineering
  • Proteins
  • RNA, Transfer
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Identity

International Standard Serial Number (ISSN)

  • 1471-0072

Digital Object Identifier (DOI)

  • 10.1038/nrm2005

PubMed ID

  • 16926858
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Additional Document Info

start page

  • 775

end page

  • 782

volume

  • 7

issue

  • 10

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