Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Modulation of anxiety and neuropeptide-y-y1 receptors by antisense oligodeoxynucleotides

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Wahlestedt, C.
  • Pich, E. M.
  • Koob, George
  • Yee, F.
  • Heilig, M.

publication date

  • January 1993

journal

  • Science  Journal

abstract

  • The function of neuropeptide Y, one of the most abundant peptide transmitters of the mammalian brain, remains unclear because of a lack of specific receptor antagonists. An antisense oligodeoxynucleotide corresponding to the NH2-terminus of the rat Y1 receptor was constructed and added to cultures of rat cortical neurons. This treatment resulted in a reduced density of Y1 (but not Y2) receptors and diminished the decrease in adenosine 3',5'-monophosphate (cAMP) usually seen after Y1 receptor activation. Repeated injection of the same oligodeoxynucleotide into the lateral cerebral ventricle of rats was followed by a similar reduction of cortical Y1 (but not Y2) receptors. Such antisense-treated animals displayed behavioral signs of anxiety. Thus, specific inhibition of neurotransmitter receptor expression can be accomplished in the living brain and demonstrates that altered central neuropeptide Y transmission produces an anxiety-like state.

subject areas

  • Animals
  • Anxiety
  • Base Sequence
  • Cells, Cultured
  • Cerebral Cortex
  • Cyclic AMP
  • Down-Regulation
  • Embryo, Mammalian
  • Learning
  • Male
  • Molecular Sequence Data
  • Neurons
  • Neuropeptide Y
  • Oligodeoxyribonucleotides
  • Oligonucleotides, Antisense
  • Polymerase Chain Reaction
  • Rats
  • Rats, Wistar
  • Receptors, Neuropeptide Y
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.8380941

PubMed ID

  • 8380941
scroll to property group menus

Additional Document Info

start page

  • 528

end page

  • 531

volume

  • 259

issue

  • 5094

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support