recent publications
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academic article
- Heeb, M. J., Mesters, R. M., Fernandez, J. A., Hackeng, T. M., Nakasone, R. K., Griffin, J. H. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation Thrombosis and Haemostasis 2013 110:275-282 DOI:10.1160/th12-12-0953 PMID:23892573 PMCID:PMC3733499
- Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, Mclgd, Schurgers, L. J., Griffin, J. H., Koenen, R. R., Hackeng, T. M. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S Journal of the American Chemical Society 2012 134:19318-19321 DOI:10.1021/ja306993t PMID:23066897
- Van de Vijver, P., Suylen, D., Dirksen, A., Dawson, P. E., Hackeng, T. M. N(epsilon)-(thiaprolyl)-lysine as a handle for site-specific protein conjugation Biopolymers 2010 94:465-474 DOI:10.1002/bip.21485 PMID:20593461
- Saller, F., Brisset, A. C., Tchaikovski, S. N., Azevedo, M., Chrast, R., Fernandez, J. A., Schapira, M., Hackeng, T. M., Griffin, J. H., Angelillo-Scherrer, A. Generation and phenotypic analysis of protein S-deficient mice Blood 2009 114:2307-2314 DOI:10.1182/blood-2009-03-209031 PMID:19567881 PMCID:PMC2745849
- Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry 2008 283:33046-33052 DOI:10.1074/jbc.M806527200 PMID:18784085 PMCID:PMC2586267
- Dirksen, A., Dirksen, S., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry Journal of the American Chemical Society 2006 128:15602-15603 DOI:10.1021/ja067189k PMID:17147365
- Dirksen, A., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of oxime ligation Angewandte Chemie-International Edition 2006 45:7581-7584 DOI:10.1002/anie.200602877 PMID:17051631
- Heeb, M. J., Koenen, R. R., Fernandez, J. A., Hackeng, T. M. Direct anticoagulant activity of protein S-C4b binding protein complex in heerlen heterozygotes and normals Journal of Thrombosis and Haemostasis 2004 2:1766-1773 DOI:10.1111/j.1538-7836.2004.00901.x PMID:15456488
- Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America 2000 97:14074-14078 DOI:10.1073/pnas.260239797 PMID:11106381 PMCID:PMC18873
- Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal 2000 349:757-764 PMID:10903136 PMCID:PMC1221202
- Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry 2000 275:12410-12415 DOI:10.1074/jbc.275.17.12410 PMID:10777524
- Fernandez, J. A., Kojima, K., Petaja, J., Hackeng, T. M., Griffin, J. H. Cardiolipin enhances protein C pathway anticoagulant activity Blood Cells Molecules and Diseases 2000 26:115-123 DOI:10.1006/bcmd.2000.0285 PMID:10753602
- Deguchi, H., Fernandez, J. A., Hackeng, T. M., Banka, C. L., Griffin, J. H. Cardiolipin is a normal component of human plasma lipoproteins Proceedings of the National Academy of Sciences of the United States of America 2000 97:1743-1748 DOI:10.1073/pnas.97.4.1743 PMID:10677528
- Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America 1999 96:10068-10073 DOI:10.1073/pnas.96.18.10068 PMID:10468563 PMCID:PMC17843
- Mounier, C. M., Hackeng, T. M., Schaeffer, F., Faure, G., Bon, C., Griffin, J. H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry 1998 273:23764-23772 DOI:10.1074/jbc.273.37.23764 PMID:9726985
- Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers 1998 46:53-63 DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6 PMID:9664841
- Kojima, Y., Heeb, M. J., Gale, A. J., Hackeng, T. M., Griffin, J. H. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va Journal of Biological Chemistry 1998 273:14900-14905 DOI:10.1074/jbc.273.24.14900 PMID:9614093
- Wang, L. L., Zoppe, M., Hackeng, T. M., Griffin, J. H., Lee, K. F., Verma, I. M. A factor IX-deficient mouse model for hemophilia B gene therapy Proceedings of the National Academy of Sciences of the United States of America 1997 94:11563-11566 DOI:10.1073/pnas.94.21.11563 PMID:9326649
- Fernandez, J. A., Hackeng, T. M., Kojima, K., Griffin, J. H. The carbohydrate moiety of factor V modulates inactivation by activated protein C Blood 1997 89:4348-4354 PMID:9192757
- Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America 1997 94:7845-7850 DOI:10.1073/pnas.94.15.7845 PMID:9223275 PMCID:PMC21517
- Heeb, M. J., Kojima, Y., Hackeng, T. M., Griffin, J. H. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Protein Science 1996 5:1883-1889 DOI:10.1002/pro.5560050914 PMID:8880912 PMCID:PMC2143529
- Griffin, J. H., Heeb, M. J., Kojima, Y., Fernandez, J. A., Kojima, K., Hackeng, T. M., Greengard, J. S. Activated protein C resistance: molecular mechanisms Thrombosis and Haemostasis 1995 74:444-448 PMID:8578503
- Fernandez, J. A., Villoutreix, B. O., Hackeng, T. M., Griffin, J. H., Bouma, B. N. Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies Biochemistry 1994 33:11073-11078 DOI:10.1021/bi00203a003 PMID:7727359