recent publications

• academic article

  • Heeb, M. J., Mesters, R. M., Fernandez, J. A., Hackeng, T. M., Nakasone, R. K., Griffin, J. H. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation Thrombosis and Haemostasis  2013 110:275-282  DOI:10.1160/th12-12-0953  PMID:23892573  PMCID:PMC3733499
  • Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, Mclgd, Schurgers, L. J., Griffin, J. H., Koenen, R. R., Hackeng, T. M. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S Journal of the American Chemical Society  2012 134:19318-19321  DOI:10.1021/ja306993t  PMID:23066897
  • Van de Vijver, P., Suylen, D., Dirksen, A., Dawson, P. E., Hackeng, T. M. N(epsilon)-(thiaprolyl)-lysine as a handle for site-specific protein conjugation Biopolymers  2010 94:465-474  DOI:10.1002/bip.21485  PMID:20593461
  • Saller, F., Brisset, A. C., Tchaikovski, S. N., Azevedo, M., Chrast, R., Fernandez, J. A., Schapira, M., Hackeng, T. M., Griffin, J. H., Angelillo-Scherrer, A. Generation and phenotypic analysis of protein S-deficient mice Blood  2009 114:2307-2314  DOI:10.1182/blood-2009-03-209031  PMID:19567881  PMCID:PMC2745849
  • Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry  2008 283:33046-33052  DOI:10.1074/jbc.M806527200  PMID:18784085  PMCID:PMC2586267
  • Dirksen, A., Dirksen, S., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry Journal of the American Chemical Society  2006 128:15602-15603  DOI:10.1021/ja067189k  PMID:17147365
  • Dirksen, A., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of oxime ligation Angewandte Chemie-International Edition  2006 45:7581-7584  DOI:10.1002/anie.200602877  PMID:17051631
  • Heeb, M. J., Koenen, R. R., Fernandez, J. A., Hackeng, T. M. Direct anticoagulant activity of protein S-C4b binding protein complex in heerlen heterozygotes and normals Journal of Thrombosis and Haemostasis  2004 2:1766-1773  DOI:10.1111/j.1538-7836.2004.00901.x  PMID:15456488
  • Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America  2000 97:14074-14078  DOI:10.1073/pnas.260239797  PMID:11106381  PMCID:PMC18873
  • Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal  2000 349:757-764  PMID:10903136  PMCID:PMC1221202
  • Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry  2000 275:12410-12415  DOI:10.1074/jbc.275.17.12410  PMID:10777524
  • Fernandez, J. A., Kojima, K., Petaja, J., Hackeng, T. M., Griffin, J. H. Cardiolipin enhances protein C pathway anticoagulant activity Blood Cells Molecules and Diseases  2000 26:115-123  DOI:10.1006/bcmd.2000.0285  PMID:10753602
  • Deguchi, H., Fernandez, J. A., Hackeng, T. M., Banka, C. L., Griffin, J. H. Cardiolipin is a normal component of human plasma lipoproteins Proceedings of the National Academy of Sciences of the United States of America  2000 97:1743-1748  DOI:10.1073/pnas.97.4.1743  PMID:10677528
  • Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America  1999 96:10068-10073  DOI:10.1073/pnas.96.18.10068  PMID:10468563  PMCID:PMC17843
  • Mounier, C. M., Hackeng, T. M., Schaeffer, F., Faure, G., Bon, C., Griffin, J. H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry  1998 273:23764-23772  DOI:10.1074/jbc.273.37.23764  PMID:9726985
  • Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers  1998 46:53-63  DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6  PMID:9664841
  • Kojima, Y., Heeb, M. J., Gale, A. J., Hackeng, T. M., Griffin, J. H. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va Journal of Biological Chemistry  1998 273:14900-14905  DOI:10.1074/jbc.273.24.14900  PMID:9614093
  • Wang, L. L., Zoppe, M., Hackeng, T. M., Griffin, J. H., Lee, K. F., Verma, I. M. A factor IX-deficient mouse model for hemophilia B gene therapy Proceedings of the National Academy of Sciences of the United States of America  1997 94:11563-11566  DOI:10.1073/pnas.94.21.11563  PMID:9326649
  • Fernandez, J. A., Hackeng, T. M., Kojima, K., Griffin, J. H. The carbohydrate moiety of factor V modulates inactivation by activated protein C Blood  1997 89:4348-4354  PMID:9192757
  • Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America  1997 94:7845-7850  DOI:10.1073/pnas.94.15.7845  PMID:9223275  PMCID:PMC21517
  • Heeb, M. J., Kojima, Y., Hackeng, T. M., Griffin, J. H. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Protein Science  1996 5:1883-1889  DOI:10.1002/pro.5560050914  PMID:8880912  PMCID:PMC2143529
  • Griffin, J. H., Heeb, M. J., Kojima, Y., Fernandez, J. A., Kojima, K., Hackeng, T. M., Greengard, J. S. Activated protein C resistance: molecular mechanisms Thrombosis and Haemostasis  1995 74:444-448  PMID:8578503
  • Fernandez, J. A., Villoutreix, B. O., Hackeng, T. M., Griffin, J. H., Bouma, B. N. Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies Biochemistry  1994 33:11073-11078  DOI:10.1021/bi00203a003  PMID:7727359