recent publications

• academic article

  • Bhaskaran, N., van Drogen, F., Ng, H. F., Kumar, R., Ekholm-Reed, S., Peter, M., Sangfelt, O., Reed, S. I. Fbw7alpha and fbw7gamma collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation Molecular and Cellular Biology  2013 33:85-97  DOI:10.1128/mcb.00288-12  PMID:23109421  PMCID:PMC3536299
  • Sangfelt, O., Cepeda, D., Malyukova, A., van Drogen, F., Reed, S. I. Both scf(cdc4 alpha) and scf(cdc4 gamma) are required for cyclin e turnover in cell lines that do not overexpress cyclin e Cell Cycle  2008 7:1075-1082  DOI:10.4161/cc.7.8.5648  PMID:18414042
  • Akhoondi, S., Sun, D., von der Lehr, N., Apostolidou, S., Klotz, K., Maljukova, A., Cepeda, D., Fiegl, H., Dofou, D., Marth, C., Mueller-Holzner, E., Corcoran, M., et al. Fbxw7/hcdc4 is a general tumor suppressor in human cancer Cancer Research  2007 67:9006-9012  DOI:10.1158/0008-5472.can-07-1320  PMID:17909001
  • van Drogen, F., Sangfelt, O., Malyukova, A., Matskova, L., Yeh, E., Means, A. R., Reed, S. I. Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms Molecular Cell  2006 23:37-48  DOI:10.1016/j.molcel.2006.05.020  PMID:16818231
  • Reed, S. E., Spruck, C. H., Sangfelt, O., van Drogen, F., Mueller-Holzner, E., Widschwendter, M., Zetterberg, A. Mutation of hcdc4 leads to cell cycle deregulation of cyclin e in cancer Cancer Research  2004 64:795-800  DOI:10.1158/0008-5472.can-03-3417  PMID:14871801
  • Spruck, C. H., Strohmaier, H., Sangfelt, O., Muller, H. M., Hubalek, M., Muller-Holzner, E., Marth, C., Widschwendter, M., Reed, S. I. Hcdc4 gene mutations in endometrial cancer Cancer Research  2002 62:4535-4539  PMID:12183400
  • Strohmaier, H., Spruck, C. H., Kaiser, P., Won, K. A., Sangfelt, O., Reed, S. I. Human f-box protein hcdc4 targets cyclin e for proteolysis and is mutated in a breast cancer cell line Nature  2001 413:316-322  DOI:10.1038/35095076  PMID:11565034