recent publications

• academic article

  • Hardouin, C., Kelso, M. J., Romero, F. A., Rayl, T. J., Leung, D., Hwang, I., Cravatt, B. F., Boger, D. L. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry  2007 50:3359-3368  DOI:10.1021/jm061414r  PMID:17559203  PMCID:PMC2531194
  • Boger, D. L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimaraes, C. R. W., Jorgensen, W. L., et al. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics Journal of Medicinal Chemistry  2005 48:1849-1856  DOI:10.1021/jm049614v  PMID:15771430  PMCID:PMC2492884
  • Leung, D., Du, W., Hardouin, C., Cheng, H., Hwang, I., Cravatt, B. F., Boger, D. L. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Bioorganic & Medicinal Chemistry Letters  2005 15:1423-1428  DOI:10.1016/j.bmcl.2004.12.085  PMID:15713400
  • Du, W., Hardouin, C., Cheng, H., Hwang, I., Boger, D. L. Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  2005 15:103-106  DOI:10.1016/j.bmcl.2004.10.025  PMID:15582420
  • Lichtman, A. H., Leung, D., Shelton, C. C., Saghatelian, A., Hardouin, C., Boger, D. L., Cravatt, B. F. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity Journal of Pharmacology and Experimental Therapeutics  2004 311:441-448  DOI:10.1124/jpet.104.069401  PMID:15229230
  • Buck, S. B., Hardouin, C., Ichikawa, S., Soenen, D. R., Gauss, C. M., Hwang, I., Swingle, M. R., Bonness, K. M., Honkanen, R. E., Boger, D. L. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition Journal of the American Chemical Society  2003 125:15694-15695  DOI:10.1021/ja038672n  PMID:14677930
  • Leung, D., Hardouin, C., Boger, D. L., Cravatt, B. F. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes Nature Biotechnology  2003 21:687-691  DOI:10.1038/nbt826  PMID:12740587