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Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression

Academic Article
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Overview

authors

  • Diez-Roux, G.
  • Argilla, M.
  • Makarenkova, Helen
  • Ko, K.
  • Lang, R. A.

publication date

  • May 1999

journal

  • Development  Journal

abstract

  • Programmed capillary regression occurs during normal development of the eye and serves as a useful model for assessing the forces that drive vascular involution. Using a combination of S-phase labeling and liposome-mediated macrophage elimination, we show that during regression, macrophages induce apoptosis of both pericytes and endothelial cells in a cell cycle stage-dependent manner. Target cells are signaled to die by macrophages approximately 15 hours after S-phase labeling and this corresponds to a point in mid-G1 phase of the cell cycle. The tight correlation between the restriction point of the cell cycle and the point where the macrophage death signal is received suggests that the mitogen, matrix and cytoskeletal signals essential for cell-cycle progression may be inhibited by macrophages as a means of inducing cell death. Furthermore, these experiments show that cells from two distinct lineages are induced to die as a consequence of macrophage action, and this provides evidence that macrophage-induced cell death may be a general phenomenon during development and homeostasis.

subject areas

  • Animals
  • Capillaries
  • Cell Cycle
  • Cell Death
  • Endothelium, Vascular
  • G1 Phase
  • Macrophages
  • Neovascularization, Physiologic
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction
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Research

keywords

  • apoptosis
  • macrophage
  • tissue regression
  • tissue remodeling
  • vascular regression
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Identity

International Standard Serial Number (ISSN)

  • 0950-1991

PubMed ID

  • 10207139
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Additional Document Info

start page

  • 2141

end page

  • 2147

volume

  • 126

issue

  • 10

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