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Induction of minor alloantigen-specific T cell subsets in vivo: recognition of processed antigen by helper but not by cytotoxic T cell precursors

Academic Article
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Overview

authors

  • Czitrom, A. A.
  • Gascoigne, Nicholas
  • Edwards, S.
  • Waterfield, D. J.

publication date

  • 1984

journal

  • Journal of Immunology  Journal

abstract

  • Primary cytotoxic T lymphocyte (CTL) and helper T (Th) cell responses were generated from regional lymph nodes of heterozygous mice sensitized in the footpad with spleen cells of parental H-2 genotype but differing for multiple minor alloantigens of the B10 background. Cytotoxic and helper responses were read after a short in vitro culture period, which did not influence the restriction specificities of in vivo sensitized T cells. We show that under these conditions, Th cell responses appear unrestricted, whereas CTL responses are restricted to the immunizing parental H-2 genotype. Furthermore, we present evidence that these two functions are mediated by distinct T cell subsets and that the in vivo induction of Lyt-2- Th cells has the appearance of being unrestricted whereas that of Lyt-2+ CTL is restricted by H-2. These findings suggest that in a primary immune response, in vivo precursors of Th cells recognize processed antigen on F1 antigen-presenting cells (clones restricted to each parental H-2 genotype are cross-sensitized) under conditions in which those of CTL only respond directly to foreign minor alloantigens on the injected stimulator cells (clones restricted to parental H-2 genotypes are not cross-immunized). This dichotomy is taken to suggest the possibility that processing of cell membrane-bound antigens is controlled at their association step with products of the major histocompatibility complex.

subject areas

  • Animals
  • Antigens, Ly
  • Antigens, Surface
  • B-Lymphocytes
  • Cytotoxicity, Immunologic
  • Epitopes
  • H-2 Antigens
  • Interleukin-2
  • Lymphocyte Activation
  • Lymphocyte Cooperation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Minor Histocompatibility Loci
  • Stem Cells
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes, Helper-Inducer
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 6202785
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Additional Document Info

start page

  • 33

end page

  • 39

volume

  • 133

issue

  • 1

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