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Sanders, R. W.

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    • Pugach, P., Ozorowski, G., Cupo, A., Ringe, R., Yasmeen, A., de Val, N., Derking, R., Kim, H. J., Korzun, J., Golabek, M., de los Reyes, K., Ketas, T. J., et al. A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene Journal of Virology  2015 89:3380-3395  DOI:10.1128/jvi.03473-14  PMID:25589637  PMCID:PMC4337520
    • Lee, J. H., Leaman, D. P., Kim, A. S., Torrents de la Peña, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S. W., Ozorowski, G., Klein, F., Burton, D. R., et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature Communications  2015 6:8167  DOI:10.1038/ncomms9167  PMID:26404402  PMCID:PMC4586043
    • Guttman, M., Cupo, A., Julien, J. P., Sanders, R. W., Wilson, I. A., Moore, J. P., Lee, K. K. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Nature Communications  2015 6:6144  DOI:10.1038/ncomms7144  PMID:25652336  PMCID:PMC4338595
    • Kong, L., Torrents de la Peña, A., Deller, M. C., Garces, F., Sliepen, K., Hua, Y., Stanfield, R. L., Sanders, R. W., Wilson, I. A. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Acta Crystallographica Section D-Biological Crystallography  2015 71:2099-2108  DOI:10.1107/s1399004715013917  PMID:26457433  PMCID:PMC4601371
    • Derking, R., Ozorowski, G., Sliepen, K., Yasmeen, A., Cupo, A., Torres, J. L., Julien, J. P., Lee, J. H., van Montfort, T., de Taeye, S. W., Connors, M., Burton, D. R., et al. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer PLoS Pathogens  2015 11:e1004767  DOI:10.1371/journal.ppat.1004767  PMID:25807248  PMCID:PMC4373910
    • Julien, J. P., Lee, J. H., Ozorowski, G., Hua, Y., Torrents de la Peña, A., de Taeye, S. W., Nieusma, T., Cupo, A., Yasmeen, A., Golabek, M., Pugach, P., Klasse, P. J., et al. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens Proceedings of the National Academy of Sciences of the United States of America  2015 112:11947-11952  DOI:10.1073/pnas.1507793112  PMID:26372963  PMCID:PMC4586835
    • Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers Science  2015 349:aac4223  DOI:10.1126/science.aac4223  PMID:26089353  PMCID:PMC4498988
    • Dosenovic, P., von Boehmer, L., Escolano, A., Jardine, J., Freund, N. T., Gitlin, A. D., McGuire, A. T., Kulp, D. W., Oliveira, T., Scharf, L., Pietzsch, J., Gray, M. D., et al. Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice Cell  2015 161:1505-1515  DOI:10.1016/j.cell.2015.06.003  PMID:26091035  PMCID:PMC4604566
    • McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al. Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies PLoS Pathogens  2015 11:e1005110  DOI:10.1371/journal.ppat.1005110  PMID:26267277  PMCID:PMC4534392
    • Hu, J. K., Crampton, J. C., Cupo, A., Ketas, T., van Gils, M. J., Sliepen, K., de Taeye, S. W., Sok, D., Ozorowski, G., Deresa, I., Stanfield, R., Ward, A. B., et al. Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity Journal of Virology  2015 89:10383-10398  DOI:10.1128/jvi.01653-15  PMID:26246566  PMCID:PMC4580201
    • Sliepen, K., Ozorowski, G., Burger, J. A., van Montfort, T., Stunnenberg, M., LaBranche, C., Montefiori, D. C., Moore, J. P., Ward, A. B., Sanders, R. W. Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity Retrovirology  2015 12:82  DOI:10.1186/s12977-015-0210-4  PMID:26410741  PMCID:PMC4583754
    • Pritchard, L. K., Vasiljevic, S., Ozorowski, G., Seabright, G. E., Cupo, A., Ringe, R., Kim, H. J., Sanders, R. W., Doores, K. J., Burton, D. R., Wilson, I. A., Ward, A. B., et al. Structural constraints determine the glycosylation of HIV-1 envelope trimers Cell Reports  2015 11:1604-1613  DOI:10.1016/j.celrep.2015.05.017  PMID:26051934  PMCID:PMC4555872
    • Huang, J., Kang, B. H., Pancera, M., Lee, J. H., Tong, T., Feng, Y., Imamichi, H., Georgiev, I. S., Chuang, G. Y., Druz, A., Doria-Rose, N. A., Laub, L., et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Nature  2014 515:138-142  DOI:10.1038/nature13601  PMID:25186731  PMCID:PMC4224615
    • Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity  2014 40:657-668  DOI:10.1016/j.immuni.2014.04.009  PMID:24768347  PMCID:PMC4070425
    • Guttman, M., Garcia, N. K., Cupo, A., Matsui, T., Julien, J. P., Sanders, R. W., Wilson, I. A., Moore, J. P., Lee, K. K. CD4-induced activation in a soluble HIV-1 Env trimer Structure  2014 22:974-984  DOI:10.1016/j.str.2014.05.001  PMID:24931470  PMCID:PMC4231881
    • Doria-Rose, N. A., Schramm, C. A., Gorman, J., Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M., Staupe, R. P., Altae-Tran, H. R., et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Nature  2014 509:55-62  DOI:10.1038/nature13036  PMID:24590074  PMCID:PMC4395007
    • Yasmeen, A., Ringe, R., Derking, R., Cupo, A., Julien, J. P., Burton, D. R., Ward, A. B., Wilson, I. A., Sanders, R. W., Moore, J. P., Klasse, P. J. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits Retrovirology  2014 11:41  DOI:10.1186/1742-4690-11-41  PMID:24884783  PMCID:PMC4067080
    • Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America  2014 111:17624-17629  DOI:10.1073/pnas.1415789111  PMID:25422458  PMCID:PMC4267403
    • Chung, N. P. Y., Matthews, K., Kim, H. J., Ketas, T. J., Golabek, M., de los Reyes, K., Korzun, J., Yasmeen, A., Sanders, R. W., Klasse, P. J., Wilson, I. A., Ward, A. B., et al. Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies Retrovirology  2014 11:33  DOI:10.1186/1742-4690-11-33  PMID:24767177  PMCID:PMC4032163
    • Blattner, C., Lee, J. H., Sliepen, K., Derking, R., Falkowska, E., de la Pena, A. T., Cupo, A., Julien, J. P., van Gils, M., Lee, P. S., Peng, W., Paulson, J. C., et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity  2014 40:669-680  DOI:10.1016/j.immuni.2014.04.008  PMID:24768348  PMCID:PMC4057017
    • Sanders, R. W., Derking, R., Cupo, A., Julien, J. P., Yasmeen, A., de Val, N., Kim, H. J., Blattner, C., de la Pena, A. T., Korzun, J., Golabek, M., de los Reyes, K., et al. A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies PLoS Pathogens  2013 9:e1003618  DOI:10.1371/journal.ppat.1003618  PMID:24068931  PMCID:PMC3777863
    • Isik, G., Chung, N. P. Y., van Montfort, T., Menis, S., Matthews, K., Schief, W. R., Moore, J. P., Sanders, R. W. An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells PLoS One  2013 8:e67309  DOI:10.1371/journal.pone.0067309  PMID:23826263  PMCID:PMC3691133
    • Julien, J. P., Lee, J. H., Cupo, A., Murin, C. D., Derking, R., Hoffenberg, S., Caulfield, M. J., King, C. R., Marozsan, A. J., Klasse, P. J., Sanders, R. W., Moore, J. P., et al. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Proceedings of the National Academy of Sciences of the United States of America  2013 110:213-218  DOI:10.1073/pnas.1217537110  PMID:23426631  PMCID:PMC3600498
    • Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens  2013 9:e1003342  DOI:10.1371/journal.ppat.1003342  PMID:23658524  PMCID:PMC3642082
    • Ringe, R. P., Sanders, R. W., Yasmeen, A., Kim, H. J., Lee, J. H., Cupo, A., Korzun, J., Derking, R., van Montfort, T., Julien, J. P., Wilson, I. A., Klasse, P. J., et al. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Proceedings of the National Academy of Sciences of the United States of America  2013 110:18256-18261  DOI:10.1073/pnas.1314351110  PMID:24145402  PMCID:PMC3831437
    • Lyumkis, D., Julien, J. P., de Val, N., Cupo, A., Potter, C. S., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Carragher, B., Wilson, I. A., Ward, A. B. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer Science  2013 342:1484-1490  DOI:10.1126/science.1245627  PMID:24179160  PMCID:PMC3954647
    • Julien, J. P., Cupo, A., Sok, D., Stanfield, R. L., Lyumkis, D., Deller, M. C., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A. Crystal structure of a soluble cleaved HIV-1 envelope trimer Science  2013 342:1477-1483  DOI:10.1126/science.1245625  PMID:24179159  PMCID:PMC3886632
    • Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology  2013 87:9873-9885  DOI:10.1128/jvi.01226-13  PMID:23824824  PMCID:PMC3754145
    • Khayat, R., Lee, J. H., Julien, J. P., Cupo, A., Klasse, P. J., Sanders, R. W., Moore, J. P., Wilson, I. A., Ward, A. B. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers Journal of Virology  2013 87:9865-9872  DOI:10.1128/jvi.01222-13  PMID:23824817  PMCID:PMC3754114
    • Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology  2013 20:796-803  DOI:10.1038/nsmb.2594  PMID:23708606  PMCID:PMC3823233
    • Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry  2012 287:24239-24254  DOI:10.1074/jbc.M112.371898  PMID:22645128  PMCID:PMC3397850
    • Van Montfort, T., Melchers, M., Isik, G., Menis, S., Huang, P. S., Matthews, K., Michael, E., Berkhout, B., Schief, W. R., Moore, J. P., Sanders, R. W. A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses Journal of Biological Chemistry  2011 286:22250-22261  DOI:10.1074/jbc.M111.229625  PMID:21515681  PMCID:PMC3121371
    • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science  2011 334:1097-1103  DOI:10.1126/science.1213256  PMID:21998254  PMCID:PMC3280215
    • Harris, A., Borgnia, M. J., Shi, D., Bartesaghi, A., He, H. F., Pejchal, R., Kang, Y., Depetris, R., Marozsan, A. J., Sanders, R. W., Klasse, P. J., Milne, J. L. S., et al. Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Proceedings of the National Academy of Sciences of the United States of America  2011 108:11440-11445  DOI:10.1073/pnas.1101414108  PMID:21709254  PMCID:PMC3136299
    • Binley, J. M., Ban, Y. E. A., Crooks, E. T., Eggink, D., Osawa, K., Schief, W. R., Sanders, R. W. Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization Journal of Virology  2010 84:5637-5655  DOI:10.1128/jvi.00105-10  PMID:20335257  PMCID:PMC2876609
    • Binley, J. M., Sanders, R. W., Master, A., Cayanan, C. S., Wiley, C. L., Schiffner, L., Travis, B., Kuhmann, S., Burton, D. R., Hu, S. L., Olson, W. C., Moore, J. P. Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins Journal of Virology  2002 76:2606-2616  DOI:10.1128/jvi.76.6.2606-2616.2002  PMID:11861826

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