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Coevolution and subsite decomposition for the design of resistance-evading HIV-1 protease inhibitors

Academic Article
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Overview

authors

  • Rosin, C. D.
  • Belew, R. K.
  • Walker, W. L.
  • Morris, G. M.
  • Olson, Arthur
  • Goodsell, David

publication date

  • March 1999

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Computational Biology
  • Computer Simulation
  • Drug Design
  • Drug Resistance, Microbial
  • Evolution, Molecular
  • HIV Protease Inhibitors
  • HIV-1
  • Models, Molecular
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Research

keywords

  • AIDS therapy
  • HIV-1 protease
  • coevolution
  • computer-aided drug design
  • drug resistance
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Identity

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1006/jmbi.1998.2579

PubMed ID

  • 10074408
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Additional Document Info

start page

  • 77

end page

  • 92

volume

  • 287

issue

  • 1

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