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Il-7 and il-15 differentially regulate cd8(+) t-cell subsets during contraction of the immune response

Academic Article
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Overview

authors

  • Rubinstein, M. P.
  • Lind, N. A.
  • Purton, J. F.
  • Filippou, P.
  • Best, J. A.
  • McGhee, P. A.
  • Surh, Charles
  • Goldrath, A. W.

publication date

  • November 2008

journal

  • Blood  Journal

abstract

  • Although it is known that interleukin-7 (IL-7) and IL-15 influence the survival and turnover of CD8+ T cells, less is known about how these cytokines affect different subsets during the course of the immune response. We find that IL-7 and IL-15 differentially regulate CD8+ T-cell subsets defined by KLRG1 and CD127 expression during the contraction phase of the immune response. The provision of IL-15, or the related cytokine IL-2, during contraction led to the preferential accumulation of KLRG1(hi)CD127(lo) CD8+ T cells, whereas provision of IL-7 instead favored the accumulation of KLRG1(lo)CD127(hi) cells. While IL-7 and IL-15 both induced proliferation of KLRG1(lo) cells, KLRG1(hi) cells exhibited an extraordinarily high level of resistance to cytokine-driven proliferation in vivo despite their dramatic accumulation upon IL-15 administration. These results suggest that IL-15 and IL-2 greatly improve the survival of KLRG1(hi) CD8+ T cells, which are usually destined to perish during contraction, without inducing proliferation. As the availability of IL-15 and IL-2 is enhanced during periods of extended inflammation, our results suggest a mechanism in which a population of cytokine-dependent KLRG1(hi) CD8+ T cells is temporarily retained for improved immunity. Consideration of these findings may aid in the development of immunotherapeutic strategies against infectious disease and cancer.

subject areas

  • Adoptive Transfer
  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Proliferation
  • Cell Survival
  • Humans
  • Interleukin-15
  • Interleukin-7
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Ovalbumin
  • Receptors, Interleukin-15
  • Receptors, Interleukin-2
  • Recombinant Proteins
  • T-Lymphocyte Subsets
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Identity

PubMed Central ID

  • PMC2572798

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2008-06-160945

PubMed ID

  • 18689546
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Additional Document Info

start page

  • 3704

end page

  • 3712

volume

  • 112

issue

  • 9

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