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Characterization of proteomic and metabolomic responses to dietary factors and supplements

Academic Article
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Overview

authors

  • Astle, J.
  • Ferguson, J. T.
  • German, J. B.
  • Harrigan, G. G.
  • Kelleher, N. L.
  • Kodadek, Thomas
  • Parks, B. A.
  • Roth, M. J.
  • Singletary, K. W.
  • Wenger, C. D.
  • Mahady, G. B.

publication date

  • December 2007

journal

  • Journal of Nutrition  Journal

abstract

  • Over the past decade there has been a renewed interest in research and development of both dietary and nutritional supplements. Significant advancements have been made in the scientific assessment of the quality, safety, and efficacy of these products because of the strong interest in and financial support of these projects. As research in both fields continues to advance, opportunities to use new and innovative research technologies and methodologies, such as proteomics and metabolomics, are critical for the future progress of the science. The purpose of the symposium was to begin the process of communicating new innovative proteomic and metabolomic methodologies that may be applied by researchers in both the nutrition and the natural product communities. This symposium highlighted 2 proteomic approaches, protein fingerprinting in complex mixtures with peptoid microarrays and top-down mass spectrometry for annotation of gene products. Likewise, an overview of the methodologies used in metabolomic profiling of natural products was presented, and an illustration of an integrated metabolomics approach in nutrition research was highlighted.

subject areas

  • Adult
  • Biological Products
  • Biomarkers
  • Diet
  • Dietary Supplements
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Male
  • Nutritional Sciences
  • Peptide Mapping
  • Polymorphism, Genetic
  • Proteomics
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Identity

International Standard Serial Number (ISSN)

  • 0022-3166

PubMed ID

  • 18029500
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Additional Document Info

start page

  • 2787

end page

  • 2793

volume

  • 137

issue

  • 12

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