recent publications

• academic article

  • Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C. H., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B., Paulsson-Berne, G., Haeggstrom, J. Z. Expression of 5-lipoxygenase and leukotriene a(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability Proceedings of the National Academy of Sciences of the United States of America  2006 103:8161-8166  DOI:10.1073/pnas.0602414103  PMID:16698924  PMCID:PMC1459628
  • Thunnissen, Mmgm, Andersson, B., Samuelsson, B., Wong, C. H., Haeggstrom, J. Z. Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors FASEB Journal  2002 16:1648-1650  DOI:10.1096/fj.01-1017fje  PMID:12207002
  • Hogg, J. H., Ollmann, I. R., Wetterholm, A., Andberg, M. B., Haeggstrom, J., Samuelsson, B., Wong, C. H. Probing the activities and mechanisms of leukotriene a(4) hydrolase with synthetic inhibitors Chemistry-a European Journal  1998 4:1698-1713  DOI:10.1002/(sici)1521-3765(19980904)4:9<1698::aid-chem1698>3.3.co;2-a
  • Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:1405-1415  DOI:10.1016/0968-0896(95)00128-4  PMID:8564408
  • Ollmann, I. R., Hogg, J. H., Munoz, B., Haeggstrom, J. Z., Samuelsson, B., Wong, C. H. Investigation of the inhibition of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:969-995  DOI:10.1016/0968-0896(95)00078-u  PMID:7582974
  • Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics  1995 275:31-37  PMID:7562564
  • Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry  1993 36:211-220  PMID:8423594
  • Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society  1992 114:6552-6553  DOI:10.1021/ja00042a041
  • Nicolaou, K. C., Marron, B. E., Veale, C. A., Webber, S. E., Dahlen, S. E., Samuelsson, B., Serhan, C. N. Identification of a novel 7-cis-11-trans-lipoxin a4 generated by human-neutrophils - total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins a4 and b4 Biochimica et Biophysica Acta  1989 1003:44-53  DOI:10.1016/0005-2760(89)90096-9  PMID:2713393
  • Ramstedt, U., Serhan, C. N., Nicolaou, K. C., Webber, S. E., Wigzell, H., Samuelsson, B. Lipoxin a-induced inhibition of human natural-killer-cell cytotoxicity - studies on stereospecificity of inhibition and mode of action Journal of Immunology  1987 138:266-270  PMID:3782800
  • Badr, K. F., Serhan, C. N., Nicolaou, K. C., Samuelsson, B. The action of lipoxin-a on glomerular microcirculatory dynamics in the rat Biochemical and Biophysical Research Communications  1987 145:408-414  DOI:10.1016/0006-291x(87)91337-4  PMID:3593345
  • Palmblad, J., Gyllenhammar, H., Ringertz, B., Serhan, C. N., Samuelsson, B., Nicolaou, K. C. The effect of lipoxin-a and lipoxin-b on functional-responses of human-granulocytes Biochemical and Biophysical Research Communications  1987 145:168-175  DOI:10.1016/0006-291x(87)91302-7  PMID:3593338
  • Puustinen, T., Webber, S. E., Nicolaou, K. C., Haeggstrom, J., Serhan, C. N., Samuelsson, B. Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human-leukocytes - conversion into lipoxin-a by cytosolic epoxide hydrolase FEBS Letters  1986 207:127-132  DOI:10.1016/0014-5793(86)80025-4  PMID:3770188
  • Serhan, C. N., Nicolaou, K. C., Webber, S. E., Veale, C. A., Dahlen, S. E., Puustinen, T. J., Samuelsson, B. Lipoxin-a - stereochemistry and biosynthesis Journal of Biological Chemistry  1986 261:6340-6345
  • Corey, E. J., Shibasaki, M., Nicolaou, K. C., Malmsten, C. L., Samuelsson, B. Simple, stereocontrolled total synthesis of a biologically-active analog of prostaglandin endoperoxides (pgh2, pgg2) Tetrahedron Letters  1976 737-740
  • Weber, P. C., Larsson, C., Anggard, E., Hamberg, M., Corey, E. J., Nicolaou, K. C., Samuelsson, B. Stimulation of renin release from rabbit renal cortex by arachidonic-acid and prostaglandin endoperoxides Circulation Research  1976 39:868-874  PMID:1000781
  • Corey, E. J., Nicolaou, K. C., Machida, Y., Malmsten, C. L., Samuelsson, B. Synthesis and biological properties of a 9,11-azo-prostanoid - highly active biochemical mimic of prostaglandin endoperoxides .9 Proceedings of the National Academy of Sciences of the United States of America  1975 72:3355-3358  DOI:10.1073/pnas.72.9.3355  PMID:1059121