recent publications
-
academic article
- Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C. H., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B., Paulsson-Berne, G., Haeggstrom, J. Z. Expression of 5-lipoxygenase and leukotriene a(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability Proceedings of the National Academy of Sciences of the United States of America 2006 103:8161-8166 DOI:10.1073/pnas.0602414103 PMID:16698924 PMCID:PMC1459628
- Thunnissen, Mmgm, Andersson, B., Samuelsson, B., Wong, C. H., Haeggstrom, J. Z. Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors FASEB Journal 2002 16:1648-1650 DOI:10.1096/fj.01-1017fje PMID:12207002
- Hogg, J. H., Ollmann, I. R., Wetterholm, A., Andberg, M. B., Haeggstrom, J., Samuelsson, B., Wong, C. H. Probing the activities and mechanisms of leukotriene a(4) hydrolase with synthetic inhibitors Chemistry-a European Journal 1998 4:1698-1713 DOI:10.1002/(sici)1521-3765(19980904)4:9<1698::aid-chem1698>3.3.co;2-a
- Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics 1995 275:31-37 PMID:7562564
- Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry 1995 3:1405-1415 DOI:10.1016/0968-0896(95)00128-4 PMID:8564408
- Ollmann, I. R., Hogg, J. H., Munoz, B., Haeggstrom, J. Z., Samuelsson, B., Wong, C. H. Investigation of the inhibition of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry 1995 3:969-995 DOI:10.1016/0968-0896(95)00078-u PMID:7582974
- Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry 1993 36:211-220 PMID:8423594
- Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society 1992 114:6552-6553 DOI:10.1021/ja00042a041
- Nicolaou, K. C., Marron, B. E., Veale, C. A., Webber, S. E., Dahlen, S. E., Samuelsson, B., Serhan, C. N. Identification of a novel 7-cis-11-trans-lipoxin a4 generated by human-neutrophils - total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins a4 and b4 Biochimica et Biophysica Acta 1989 1003:44-53 DOI:10.1016/0005-2760(89)90096-9 PMID:2713393
- Badr, K. F., Serhan, C. N., Nicolaou, K. C., Samuelsson, B. The action of lipoxin-a on glomerular microcirculatory dynamics in the rat Biochemical and Biophysical Research Communications 1987 145:408-414 DOI:10.1016/0006-291x(87)91337-4 PMID:3593345
- Palmblad, J., Gyllenhammar, H., Ringertz, B., Serhan, C. N., Samuelsson, B., Nicolaou, K. C. The effect of lipoxin-a and lipoxin-b on functional-responses of human-granulocytes Biochemical and Biophysical Research Communications 1987 145:168-175 DOI:10.1016/0006-291x(87)91302-7 PMID:3593338
- Ramstedt, U., Serhan, C. N., Nicolaou, K. C., Webber, S. E., Wigzell, H., Samuelsson, B. Lipoxin a-induced inhibition of human natural-killer-cell cytotoxicity - studies on stereospecificity of inhibition and mode of action Journal of Immunology 1987 138:266-270 PMID:3782800
- Serhan, C. N., Nicolaou, K. C., Webber, S. E., Veale, C. A., Dahlen, S. E., Puustinen, T. J., Samuelsson, B. Lipoxin-a - stereochemistry and biosynthesis Journal of Biological Chemistry 1986 261:6340-6345
- Puustinen, T., Webber, S. E., Nicolaou, K. C., Haeggstrom, J., Serhan, C. N., Samuelsson, B. Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human-leukocytes - conversion into lipoxin-a by cytosolic epoxide hydrolase FEBS Letters 1986 207:127-132 DOI:10.1016/0014-5793(86)80025-4 PMID:3770188
- Corey, E. J., Shibasaki, M., Nicolaou, K. C., Malmsten, C. L., Samuelsson, B. Simple, stereocontrolled total synthesis of a biologically-active analog of prostaglandin endoperoxides (pgh2, pgg2) Tetrahedron Letters 1976 737-740
- Weber, P. C., Larsson, C., Anggard, E., Hamberg, M., Corey, E. J., Nicolaou, K. C., Samuelsson, B. Stimulation of renin release from rabbit renal cortex by arachidonic-acid and prostaglandin endoperoxides Circulation Research 1976 39:868-874 PMID:1000781
- Corey, E. J., Nicolaou, K. C., Machida, Y., Malmsten, C. L., Samuelsson, B. Synthesis and biological properties of a 9,11-azo-prostanoid - highly active biochemical mimic of prostaglandin endoperoxides .9 Proceedings of the National Academy of Sciences of the United States of America 1975 72:3355-3358 DOI:10.1073/pnas.72.9.3355 PMID:1059121