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The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage

Academic Article
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Overview

authors

  • Rhind, N.
  • Russell, Paul

publication date

  • August 1998

journal

  • Genetics  Journal

abstract

  • We have identified an S-phase DNA damage checkpoint in Schizosaccharomyces pombe. This checkpoint is dependent on Rad3, the S. pombe homolog of the mammalian ATM/ATR checkpoint proteins, and Cds1. Cds1 had previously been believed to be involved only in the replication checkpoint. The requirement of Cds1 in the DNA damage checkpoint suggests that Cds1 may be a general target of S-phase checkpoints. Unlike other checkpoints, the S. pombe S-phase DNA damage checkpoint discriminates between different types of damage. UV-irradiation, which causes base modification that can be repaired during G1 and S-phase, invokes the checkpoint, while gamma-irradiation, which causes double-stranded breaks that cannot be repaired by a haploid cell if induced before replication, does not invoke the checkpoint. Because the same genes are required to respond to UV- and gamma-irradiation during G2, this discrimination may represent an active suppression of the gamma response during S-phase.

subject areas

  • Adenosine Triphosphatases
  • Checkpoint Kinase 2
  • DNA Damage
  • DNA Helicases
  • DNA, Fungal
  • G1 Phase
  • Gamma Rays
  • Genes, Fungal
  • Mutation
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • S Phase
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces
  • Ultraviolet Rays
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Identity

PubMed Central ID

  • PMC1460286

International Standard Serial Number (ISSN)

  • 0016-6731

PubMed ID

  • 9691032
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Additional Document Info

start page

  • 1729

end page

  • 1737

volume

  • 149

issue

  • 4

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