recent publications
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academic article
- Arnold, C. N., Xia, Y., Lin, P., Ross, C., Schwander, M., Smart, N. G., Muller, U., Beutler, B. Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis Genetics 2011 187:633-641 DOI:10.1534/genetics.110.124586 PMID:21196518 PMCID:PMC3063661
- Schwander, M., Kachar, B., Muller, U. The cell biology of hearing Journal of Cell Biology 2010 190:9-20 DOI:10.1083/jcb.201001138 PMID:20624897 PMCID:PMC2911669
- Pangrsic, T., Lasarow, L., Reuter, K., Takago, H., Schwander, M., Riedel, D., Frank, T., Tarantino, L. M., Bailey, J. S., Strenzke, N., Brose, N., Muller, U., et al. Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells Nature Neuroscience 2010 13:869-876 DOI:10.1038/nn.2578 PMID:20562868
- Schwander, M., Lopes, V., Sczaniecka, A., Gibbs, D., Lillo, C., Delano, D., Tarantino, L. M., Wiltshire, T., Williams, D. S., Muller, U. A novel allele of myosin viia reveals a critical function for the c-terminal ferm domain for melanosome transport in retinal pigment epithelial cells Journal of Neuroscience 2009 29:15810-15818 DOI:10.1523/jneurosci.4876-09.2009 PMID:20016096 PMCID:PMC2834289
- Grillet, N., Schwander, M., Hildebrand, M. S., Sczaniecka, A., Kolatkar, A., Velasco, J., Webster, J. A., Kahrizi, K., Najmabadi, H., Kimberling, W. J., Stephan, D., Bahlo, M., et al. Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans American Journal of Human Genetics 2009 85:328-337 DOI:10.1016/j.ajhg.2009.07.017 PMID:19732867 PMCID:PMC2771534
- Grillet, N., Kazmierczak, P., Xiong, W., Schwander, M., Reynolds, A., Sakaguchi, H., Tokita, J., Kachar, B., Muller, U. The mechanotransduction machinery of hair cells Science Signaling 2009 2:pt5 DOI:10.1126/scisignal.285pt5 PMID:19706872
- Grillet, N., Xiong, W., Reynolds, A., Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., et al. Harmonin mutations cause mechanotransduction defects in cochlear hair cells Neuron 2009 62:375-387 DOI:10.1016/j.neuron.2009.04.006 PMID:19447093 PMCID:PMC2691393
- Schwander, M., Xiong, W., Tokita, J., Lelli, A., Elledge, H. M., Kazmierczak, P., Sczaniecka, A., Kolatkar, A., Wiltshire, T., Kuhn, P., Holt, J. R., Kachar, B., et al. A mouse model for nonsyndromic deafness (dfnb12) links hearing loss to defects in tip links of mechanosensory hair cells Proceedings of the National Academy of Sciences of the United States of America 2009 106:5252-5257 DOI:10.1073/pnas.0900691106 PMID:19270079 PMCID:PMC2664065
- Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America 2008 105:14609-14614 DOI:10.1073/pnas.0807219105 PMID:18794526 PMCID:PMC2567147
- Conti, F. J., Felder, A., Monkley, S., Schwander, M., Wood, M. R., Lieber, R., Critchley, D., Mueller, U. Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle Development 2008 135:2043-2053 DOI:10.1242/dev.015818 PMID:18434420 PMCID:PMC2562324
- Wang, H. V., Chang, L. W., Brixius, K., Wickstrom, S. A., Montanez, E., Thievessen, I., Schwander, M., Muller, U., Bloch, W., Mayer, U., Fassler, R. Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage Journal of Cell Biology 2008 180:1037-1049 DOI:10.1083/jcb.200707175 PMID:18332223 PMCID:PMC2265410
- Schwander, M., Sczaniecka, A., Grillet, N., Bailey, J. S., Avenarius, M., Najmabadi, H., Steffy, B. M., Federe, G. C., Lagler, E. A., Banan, R., Hice, R., Grabowski-Boase, L., et al. A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function Journal of Neuroscience 2007 27:2163-2175 DOI:10.1523/jneurosci.4975-06.2007 PMID:17329413
- Herr, D. R., Grillet, N., Schwander, M., Rivera, R., Muller, U., Chun, J. Sphingosine 1-phosphate S1P signaling is required for maintenance of hair cells mainly via activation of S1P2 Journal of Neuroscience 2007 27:1474-1478 DOI:10.1523/jneurosci.4245-06.2007 PMID:17287522
- Senften, M., Schwander, M., Kazmierczak, P., Lillo, C., Shin, J. B., Hasson, T., Geleoc, G. S. G., Gillespie, P. G., Williams, D., Holt, J. R., Muller, U. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells Journal of Neuroscience 2006 26:2060-2071 DOI:10.1523/jneurosci.4521-05.2006 PMID:16481439 PMCID:PMC2712835
- Schwander, M., Shirasaki, R., Pfaff, S. L., Muller, U. Beta 1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation Journal of Neuroscience 2004 24:8181-8191 DOI:10.1523/jneurosci.1345-04.2004 PMID:15371519
- Leu, M., Bellmunt, E., Schwander, M., Farinas, I., Brenner, H. R., Muller, U. Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development Development 2003 130:2291-2301 DOI:10.1242/dev.00447 PMID:12702645
- Schwander, M., Leu, M., Stumm, M., Dorchies, O. M., Ruegg, U. T., Schittny, J., Muller, U. Beta 1 integrins regulate myoblast fusion and sarcomere assembly Developmental Cell 2003 4:673-685 DOI:10.1016/s1534-5807(03)00118-7 PMID:12737803