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Chronic nicotine treatment counteracts dopamine d-2 receptor up-regulation induced by a partial meso-diencephalic hemitransection in the rat

Academic Article
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Overview

authors

  • Janson, A. M.
  • Hedlund, Peter
  • Fuxe, K.
  • Voneuler, G.

publication date

  • August 1994

journal

  • Brain Research  Journal

abstract

  • To further elucidate the previously demonstrated protective actions of nicotine on lesioned nigrostriatal dopamine (DA) systems (Janson and Møller, Neuroscience, 57 (1993) 931-941), the present receptor binding experiments were carried out. Rats were partially hemitransected at the meso-diencephalic junction and the effects of chronic continuous (-)nicotine treatment (osmotic pumps s.c., 0.125 mg/kg/h, 14 days) on [3H]N-propylnorapomorphine ([3H]NPA) and [3H]methylcarbamylcholine ([3H]MCC) binding were investigated in striatal coronal sections to study the agonist binding sites of DA D2 receptors and nicotinic cholinoceptors, respectively. In saline-treated but not in nicotine-treated rats, the lesion led to an increased Bmax value of [3H]NPA binding. The Bmax value of [3H]MCC binding was increased by nicotine treatment and decreased by the partial hemitransection. These results indicate that chronic nicotine treatment counteracts the lesion-induced upregulation of the high-affinity agonist binding site of the DA D2 receptor, which may be explained by an increased presence of DA via a protective effect of nicotine on neostriatal DA terminals. This action of nicotine may be of interest in the treatment of neurodegenerative diseases such as Parkinson's disease.

subject areas

  • Animals
  • Apomorphine
  • Autoradiography
  • Carbachol
  • Diencephalon
  • Dopamine Agonists
  • Ligands
  • Male
  • Mesencephalon
  • Nicotine
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D2
  • Receptors, Nicotinic
  • Up-Regulation
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Research

keywords

  • DOPAMINE
  • LESION
  • NEOSTRIATUM
  • NICOTINE
  • PROTECTION
  • [H-3] METHYLCARBAMYLCHOLINE
  • [H-3] N-PROPYLNORAPOMORPHINE
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(94)91593-8

PubMed ID

  • 7812781
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Additional Document Info

start page

  • 25

end page

  • 32

volume

  • 655

issue

  • 1-2

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