recent publications
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academic article
- Tsutakawa, S. E., Yan, C., Xu, X., Weinacht, C. P., Freudenthal, B. D., Yang, K., Zhuang, Z., Washington, M. T., Tainer, J. A., Ivanov, I. Structurally distinct ubiquitin- and SUMO-Modified PCNA: implications for their distinct roles in the DNA damage response Structure 2015 23:724-733 DOI:10.1016/j.str.2015.02.008 PMID:25773143 PMCID:PMC4394044
- Tsutakawa, S. E., Lafrance-Vanasse, J., Tainer, J. A. The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once DNA Repair 2014 19:95-107 DOI:10.1016/j.dnarep.2014.03.022 PMID:24754999 PMCID:PMC4051888
- Hegde, M. L., Tsutakawa, S. E., Hegde, P. M., Holthauzen, L. M., Li, J., Oezguen, N., Hilser, V. J., Tainer, J. A., Mitra, S. The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions Journal of Molecular Biology 2013 425:2359-2371 DOI:10.1016/j.jmb.2013.03.030 PMID:23542007 PMCID:PMC3779128
- Tsutakawa, S. E., Shin, D. S., Mol, C. D., Izumi, T., Arvai, A. S., Mantha, A. K., Szczesny, B., Ivanov, I. N., Hosfield, D. J., Maiti, B., Pique, M. E., Frankel, K. A., et al. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes Journal of Biological Chemistry 2013 288:8445-8455 DOI:10.1074/jbc.M112.422774 PMID:23355472 PMCID:PMC3605660
- Brosey, C. A., Yan, C., Tsutakawa, S. E., Heller, W. T., Rambo, R. P., Tainer, J. A., Ivanov, I., Chazin, W. J. A new structural framework for integrating replication protein A into DNA processing machinery Nucleic Acids Research 2013 41:2313-2327 DOI:10.1093/nar/gks1332 PMID:23303776 PMCID:PMC3575853
- Shi, K., Kurahashi, K., Gao, R., Tsutakawa, S. E., Tainer, J. A., Pommier, Y., Aihara, H. Structural basis for recognition of 5 '-phosphotyrosine adducts by tdp2 Nature Structural & Molecular Biology 2012 19:1372-7 DOI:10.1038/nsmb.2423 PMID:23104058 PMCID:PMC3515695
- Querol-Audi, J., Yan, C. L., Xu, X. J., Tsutakawa, S. E., Tsai, M. S., Tainer, J. A., Cooper, P. K., Nogales, E., Ivanov, I. Repair complexes of fen1 endonuclease, DNA, and rad9-hus1-rad1 are distinguished from their pcna counterparts by functionally important stability Proceedings of the National Academy of Sciences of the United States of America 2012 109:8528-8533 DOI:10.1073/pnas.1121116109 PMID:22586102 PMCID:PMC3365210
- Tsutakawa, S. E., Tainer, J. A. Double strand binding-single strand incision mechanism for human flap endonuclease: Implications for the superfamily Mechanisms of Ageing and Development 2012 133:195-202 DOI:10.1016/j.mad.2011.11.009 PMID:22244820 PMCID:PMC3345168
- Grasby, J. A., Finger, L. D., Tsutakawa, S. E., Atack, J. M., Tainer, J. A. Unpairing and gating: Sequence-independent substrate recognition by fen superfamily nucleases Trends in Biochemical Sciences 2012 37:74-84 DOI:10.1016/j.tibs.2011.10.003 PMID:22118811 PMCID:PMC3341984
- Tsutakawa, S. E., Van Wynsberghe, A. W., Freudenthal, B. D., Weinacht, C. P., Gakhar, L., Washington, M. T., Zhuang, Z. H., Tainer, J. A., Ivanov, I. Solution x-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on pcna Proceedings of the National Academy of Sciences of the United States of America 2011 108:17672-17677 DOI:10.1073/pnas.1110480108 PMID:22006297 PMCID:PMC3203759
- Tsutakawa, S. E., Classen, S., Chapados, B. R., Arvai, A. S., Finger, L. D., Guenther, G., Tomlinson, C. G., Thompson, P., Sarker, A. H., Shen, B. H., Cooper, P. K., Grasby, J. A., et al. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the fen1 superfamily Cell 2011 145:198-211 DOI:10.1016/j.cell.2011.03.004 PMID:21496641 PMCID:PMC3086263
- Lintner, N. G., Frankel, K. A., Tsutakawa, S. E., Alsbury, D. L., Copie, V., Young, M. J., Tainer, J. A., Lawrence, C. M. The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system Journal of Molecular Biology 2011 405:939-955 DOI:10.1016/j.jmb.2010.11.019 PMID:21093452 PMCID:PMC4507800
- Hura, G. L., Menon, A. L., Hammel, M., Rambo, R. P., Poole, F. L., 2nd, Tsutakawa, S. E., Jenney, F. E., Jr., Classen, S., Frankel, K. A., Hopkins, R. C., Yang, S. J., Scott, J. W., et al. Robust, high-throughput solution structural analyses by small angle x-ray scattering (saxs) Nature Methods 2009 6:606-612 DOI:10.1038/nmeth.1353 PMID:19620974 PMCID:PMC3094553
- Min, X. S., Akella, R., He, H. X., Humphreys, J. M., Tsutakawa, S. E., Lee, S. J., Tainer, J. A., Cobb, M. H., Goldsmith, E. J. The structure of the map2k mek6 reveals an autoinhibitory dimer Structure 2009 17:96-104 DOI:10.1016/j.str.2008.11.007 PMID:19141286 PMCID:PMC3689539
- Edwards, R. A., Lee, M. S., Tsutakawa, S. E., Williams, R. S., Tainer, J. A., Glover, J. N. M. The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Biochemistry 2008 47:11446-11456 DOI:10.1021/bi801115g PMID:18842000 PMCID:PMC2654182
- Tsutakawa, S. E., Hura, G. L., Frankel, K. A., Cooper, P. K., Tainer, J. A. Structural analysis of flexible proteins in solution by small angle x-ray scattering combined with crystallography Journal of Structural Biology 2007 158:214-223 DOI:10.1016/j.jsb.2006.09.008 PMID:17182256
- Sarker, A. H., Tsutakawa, S. E., Kostek, S., Ng, C., Shin, D. S., Peris, M., Campeau, E., Tainer, J. A., Nogales, E., Cooper, P. K. Recognition of rna polymerase ii and transcription bubbles by xpg, csb, and tfiih: Insights for transcription-coupled repair and cockayne syndrome Molecular Cell 2005 20:187-198 DOI:10.1016/j.molcel.2005.09.022 PMID:16246722