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Hypertonic saline mimics the effects of vasopressin and social recognition in rats

Academic Article
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Overview

authors

  • Bluthe, R. M.
  • Koob, George
  • Dantzer, R.

publication date

  • December 1991

journal

  • Behavioural Pharmacology  Journal

abstract

  • Injection of hypertonic saline to adult male rats following exposure to a juvenile, at a dose known to release peripheral and central vasopressin (10ml/kg i.p. of an 0.5M solution), decreased social exploration of the same juvenile when it was presented 2h later. This effect of hypertonic saline was blocked by pretreatment with subcutaneous injection of 30mg/kg dPTyr (Me) AVP, an antagonist of the vasopressor receptors of vasopressin, in intact but not in castrated male rats. These results are interpreted in terms of the involvement of androgen-dependent vasopressinergic neurotransmission in social recognition.
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Research

keywords

  • HYPERTONIC SALINE
  • RAT
  • SOCIAL RECOGNITION TEST
  • VASOPRESSIN
  • VASOPRESSOR RECEPTORS
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Identity

International Standard Serial Number (ISSN)

  • 0955-8810

PubMed ID

  • 11224093
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Additional Document Info

start page

  • 513

end page

  • 516

volume

  • 2

issue

  • 6

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