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The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

Academic Article
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Overview

authors

  • BaccalĂ , Roberto
  • Theofilopoulos, Argyrios

publication date

  • 2005

journal

  • Trends in Immunology  Journal

abstract

  • In lymphopenic conditions, T cells expand to re-establish homeostasis by a process dependent on self-peptide-MHC recognition and the availability of proliferation- and survival-promoting cytokines. Although physiologically normal, chronic recurrence of this process might lead to selection of high-affinity self-reactive T-cell clones and autoimmune disease in susceptible individuals. A recent study in a diabetes-prone mouse model has provided strong evidence to support this hypothesis.

subject areas

  • Animals
  • Autoimmunity
  • Cell Proliferation
  • Disease Models, Animal
  • Homeostasis
  • Humans
  • Mice
  • Models, Biological
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2004.11.006

PubMed ID

  • 15629402
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Additional Document Info

start page

  • 5

end page

  • 8

volume

  • 26

issue

  • 1

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