Enantioselective aldol cyclodehydrations catalyzed by antibody 38c2

Academic Article

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Overview

authors

• List, B.
• Lerner, Richard
• Barbas III, Carlos

publication date

• 1999

journal

• Organic Letters  Journal

abstract

• [formula: see text] Aldolase antibody 38C2 catalyzes the enantioselective aldol cyclodehydration of 4-substituted-2,6-heptanediones (3) to give enantiomerically enriched 5-substituted-3-methyl-2-cyclohexen-1-ones (4). Yields, enantioselectivities, and product purities are markedly increased compared to the L-proline-catalyzed reactions.

subject areas

• Aldehydes
• Antibodies, Catalytic
• Catalysis
• Chromatography, High Pressure Liquid
• Cyclization
• Cyclohexanones
• Fructose-Bisphosphate Aldolase
• Immunoglobulin Fab Fragments
• Proline
• Stereoisomerism

Identity

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol9905405

PubMed ID

• 10822533

Additional Document Info

start page

• 59

end page

• 61

volume

• 1

issue

• 1