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Enantioselective aldol cyclodehydrations catalyzed by antibody 38c2

Academic Article
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Overview

authors

  • List, B.
  • Lerner, Richard
  • Barbas III, Carlos

publication date

  • 1999

journal

  • Organic Letters  Journal

abstract

  • [formula: see text] Aldolase antibody 38C2 catalyzes the enantioselective aldol cyclodehydration of 4-substituted-2,6-heptanediones (3) to give enantiomerically enriched 5-substituted-3-methyl-2-cyclohexen-1-ones (4). Yields, enantioselectivities, and product purities are markedly increased compared to the L-proline-catalyzed reactions.

subject areas

  • Aldehydes
  • Antibodies, Catalytic
  • Catalysis
  • Chromatography, High Pressure Liquid
  • Cyclization
  • Cyclohexanones
  • Fructose-Bisphosphate Aldolase
  • Immunoglobulin Fab Fragments
  • Proline
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol9905405

PubMed ID

  • 10822533
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Additional Document Info

start page

  • 59

end page

  • 61

volume

  • 1

issue

  • 1

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