Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Neurobiological mechanisms in the transition from drug use to drug dependence

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Koob, George
  • Ahmed, S. H.
  • Boutrel, B.
  • Chen, S. A.
  • Kenny, Paul
  • Markou, A.
  • O'Dell, L. E.
  • Parsons, Loren (Larry)
  • Sanna, Pietro

publication date

  • January 2004

journal

  • Neuroscience and Biobehavioral Reviews  Journal

abstract

  • Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss of control over intake, and impairment in social and occupational function. Animal models have been developed for various stages of the addiction cycle with a focus in our work on the motivational effects of drug dependence. A conceptual framework focused on allostatic changes in reward function that lead to excessive drug intake provides a heuristic framework with which to identify the neurobiologic mechanisms involved in the development of drug addiction. Neuropharmacologic studies in animal models have provided evidence for the dysregulation of specific neurochemical mechanisms in specific brain reward and stress circuits that provide the negative motivational state that drives addiction. The allostatic model integrates molecular, cellular and circuitry neuroadaptations in brain motivational systems produced by chronic drug ingestion with genetic vulnerability, and provides a new opportunity to translate advances in animal studies to the human condition.

subject areas

  • Adaptation, Physiological
  • Animals
  • Behavior, Addictive
  • Brain
  • Cocaine
  • Dose-Response Relationship, Drug
  • Heroin
  • Narcotics
  • Neuroanatomy
  • Neuropharmacology
  • Reinforcement (Psychology)
  • Substance-Related Disorders
scroll to property group menus

Research

keywords

  • drug dependence allostasis
  • dysregulation
  • vulnerability
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0149-7634

Digital Object Identifier (DOI)

  • 10.1016/j.neubiorev.2003.11.007

PubMed ID

  • 15019424
scroll to property group menus

Additional Document Info

start page

  • 739

end page

  • 749

volume

  • 27

issue

  • 8

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support