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Interleukin-6 and interstitial cystitis

Academic Article
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Overview

authors

  • Lotz, Martin
  • Villiger, P.
  • Hugli, T.
  • Koziol, James
  • Zuraw, B. L.

publication date

  • September 1994

journal

  • Journal of Urology  Journal

abstract

  • We analyzed the presence of the cytokine interleukin-6 in urine samples from interstitial cystitis patients. Interleukin-6 was significantly elevated in patients with interstitial cystitis (169.29 +/- 90.81 pg./ml. versus 34.8 +/- 6.35 pg./ml. in controls). Representative urine samples were analyzed with specific antibody to interleukin-6 and greater than 80% of the biological activity was neutralized. These cytokine measurements were then compared with clinical parameters and interleukin-6 levels correlated positively with the pain scores. Studies on the potential cellular origin of interleukin-6 showed increased levels in spontaneously voided urine but not in ureteral urine, which was collected during cystoscopy, suggesting that interleukin-6 is the product of activated cells in the bladder. This finding is supported by in situ hybridization analyses, which showed that interleukin-6 messenger ribonucleic acid expressing cells are located in the interstitium and epithelial layer, and within blood vessels. The implications of these findings for interstitial cystitis pathogenesis are discussed.

subject areas

  • Base Sequence
  • Cystitis
  • Epithelium
  • Humans
  • In Situ Hybridization
  • Interleukin-6
  • Molecular Sequence Data
  • RNA Probes
  • RNA, Messenger
  • Urinary Bladder
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Research

keywords

  • CYSTITIS, BLADDER DISEASES, INTERLEUKIN-6
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Identity

International Standard Serial Number (ISSN)

  • 0022-5347

PubMed ID

  • 8051739
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Additional Document Info

start page

  • 869

end page

  • 873

volume

  • 152

issue

  • 3

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