recent publications

• academic article

  • Zou, L., Paton, R. S., Eschenmoser, A., Newhouse, T. R., Baran, P. S., Houk, K. N. Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study Journal of Organic Chemistry  2013 78:4037-4048  DOI:10.1021/jo400350v  PMID:23461537  PMCID:PMC3631471
  • Gotoh, H., Sears, J. E., Eschenmoser, A., Boger, D. L. New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction Journal of the American Chemical Society  2012 134:13240-13243  DOI:10.1021/ja306229x  PMID:22856867  PMCID:PMC3430138
  • Chen, K., Eschenmoser, A., Baran, P. S. Strain release in C-H bond activation? Angewandte Chemie-International Edition  2009 48:9705-9708  DOI:10.1002/anie.200904474  PMID:19937877  PMCID:PMC2879134
  • Ebert, M. O., Mang, C., Krishnamurthy, R., Eschenmoser, A., Jaun, B. The structure of a TNA-TNA complex in solution: NMR study of the octamer duplex derived from alpha-(L)-threofuranosyl-(3 '-2 ')-CGAATTCG Journal of the American Chemical Society  2008 130:15105-15115  DOI:10.1021/ja8041959  PMID:18928287
  • Mittapalli, G. K., Reddy, K. R., Xiong, H., Munoz, O., Han, B., De Riccardis, F., Krishnamurthy, R., Eschenmoser, A. Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides and oligodipeptoids tagged with triazines as recognition elements Angewandte Chemie-International Edition  2007 46:2470-2477  DOI:10.1002/anie.200603207  PMID:17111452
  • Mittapalli, G. K., Osornio, Y. M., Guerrero, M. A., Reddy, K. R., Krishnamurthy, R., Eschenmoser, A. Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements Angewandte Chemie-International Edition  2007 46:2478-2484  DOI:10.1002/anie.200603209  PMID:17111453
  • Han, B., Rajwanshi, V., Nandy, J., Krishnamurthy, R., Eschenmoser, A. Mannich-type C-nucleosidations with 7-carba-purines and 4-aminopyrimidines Synlett  2005 744-750  DOI:10.1055/s-2005-864789
  • Wagner, T., Han, B., Koch, G., Krishnamurthy, R., Eschenmoser, A. Tautomerism in 5,8-diaza-7,9-dicarbaguanine ('alloguanine') Helvetica Chimica Acta  2005 88:1960-1968  DOI:10.1002/hlca.200590150
  • Ferencic, M., Reddy, G., Wu, X. L., Guntha, S., Nandy, J., Krishnamurthy, R., Eschenmoser, A. Base-pairing systems related to TNA containing phosphoramidate linkages: Synthesis of building blocks and pairing properties Chemistry & Biodiversity  2004 1:939-979  DOI:10.1002/cbdv.200490083  PMID:17191894
  • Nyffeler, P. T., Boyle, N. A., Eltepu, L., Wong, C. H., Eschenmoser, A., Lerner, R. A., Wentworth, P. Dihydrogen trioxide (hoooh) is generated during the thermal reaction between hydrogen peroxide and ozone Angewandte Chemie-International Edition  2004 43:4656-4659  DOI:10.1002/anie.200460457  PMID:15317003
  • Han, B., Jaun, B., Krishnamurthy, R., Eschenmoser, A. Mannich-type C-nucleosidations in the 5,8-diaza-7,9-dicarba-purine family Organic Letters  2004 6:3691-3694  DOI:10.1021/ol048649m  PMID:15469325
  • Zhang, Q. H., Powers, E. T., Nieva, J., Huff, M. E., Dendle, M. A., Bieschke, J., Glabe, C. G., Eschenmoser, A., Wentworth, P., Lerner, R. A., Kelly, J. W. Metabolite-initiated protein misfolding may trigger Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America  2004 101:4752-4757  DOI:10.1073/pnas.0400924101  PMID:15034169  PMCID:PMC387320
  • Zhu, X. Y., Wentworth, A. D., Wentworth, P., Eschenmoser, A., Lerner, R. A., Wilson, I. A. Probing the anti body-catalyzed water-oxidation pathway at atomic resolution Proceedings of the National Academy of Sciences of the United States of America  2004 101:2247-2252  DOI:10.1073/pnas.0307311101  PMID:14982995  PMCID:PMC356936
  • Wang, Z. J., Huynh, H. K., Han, B., Krishnamurthy, R., Eschenmoser, A. 2,6-diamino-5,8-diaza-7,9-dicarba-purine Organic Letters  2003 5:2067-2070  DOI:10.1021/ol030044n  PMID:12790530
  • Han, B., Wang, Z. J., Jaun, B., Krishnamurthy, R., Eschenmoser, A. C-nucleosidations with 2,6-diamino-5,8-diaza-7,9-dicarba-purine Organic Letters  2003 5:2071-2074  DOI:10.1021/ol030043v  PMID:12790531
  • Wentworth, P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A. D., Dilley, R. B., DeLaria, G. A., Saven, A., Babior, B. M., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for ozone formation in human atherosclerotic arteries Science  2003 302:1053-1056  DOI:10.1126/science.1089525  PMID:14605372
  • Wentworth, P., Wentworth, A. D., Zhu, X. Y., Wilson, I. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens Proceedings of the National Academy of Sciences of the United States of America  2003 100:1490-1493  DOI:10.1073/pnas.0437831100  PMID:12576548  PMCID:PMC149858
  • Pitsch, S., Wendeborn, S., Krishnamurthy, R., Holzner, A., Minton, M., Bolli, M., Miculca, C., Windhab, N., Micura, R., Stanek, M., Jaun, B., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. 9th Communication. The β-D-ribopyranosyl-(4′ -> 2′)-oligonucleotide system (‘pyranosyl-RNA’): synthesis and resumé of base-pairing properties Helvetica Chimica Acta  2003 86:4270-4363  DOI:10.1002/hlca.200390349
  • Jungmann, O., Beier, M., Luther, A., Huynh, H. K., Ebert, M. O., Jaun, B., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Communication No. 13. The α-L-arabinopyranosyl-(4′ -> 2′)-oligonucleotide system: synthesis and pairing properties Helvetica Chimica Acta  2003 86:1259-1308  DOI:10.1002/hlca.200390118
  • Pallan, P. S., Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M. Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis Angewandte Chemie-International Edition  2003 42:5893-5895  DOI:10.1002/anie.200352553  PMID:14673929
  • Wu, X. L., Delgado, G., Krishnamurthy, R., Eschenmoser, A. 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations Organic Letters  2002 4:1283-1286  DOI:10.1021/ol020016p  PMID:11950343
  • Wu, X. L., Guntha, S., Ferencic, M., Krishnamurthy, R., Eschenmoser, A. Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages Organic Letters  2002 4:1279-1282  DOI:10.1021/ol020015x  PMID:11950342
  • Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M. Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3 '-> 2 ') nucleosides: A four-carbon sugar is easily accommodated into the backbone of DNA Journal of the American Chemical Society  2002 124:13716-13721  DOI:10.1021/ja0207807  PMID:12431101
  • Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation Science  2002 298:2195-2199  DOI:10.1126/science.1077642  PMID:12434011
  • Ebert, M. O., Luther, A., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A., Jaun, B. NMR solution structure of the duplex formed by self-pairing of α-L-arabinopyranosyl-(4′ -> 2′)-(CGAATTCG) Helvetica Chimica Acta  2002 85:4055-4073  DOI:10.1002/1522-2675(200211)85:11<4055::aid-hlca4055>3.0.co;2-j
  • Wagner, T., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Communication No. 12. The β-D-xylopyranosyl-(4′ -> 2′)-oligonucleotide system Helvetica Chimica Acta  2002 85:399-416  DOI:10.1002/1522-2675(200202)85:2<399::aid-hlca399>3.0.co;2-2
  • Schoning, K. U., Scholz, P., Wu, X. L., Guntha, S., Delgado, G., Krishnamurthy, R., Eschenmoser, A. The α-L-threofuranosyl-(3'-2')-oligonucleotide system ('TNA'): synthesis and pairing properties Helvetica Chimica Acta  2002 85:4111-4153  DOI:10.1002/hlca.200290000
  • Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Antibody catalysis of the oxidation of water Science  2001 293:1806-1811  DOI:10.1126/science.1062722  PMID:11546867
  • Reck, F., Wippo, H., Kudick, R., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems, Communication No. 10. The α-L-Lyxopyranosyl-(4' -> 2′)-oligonucleotide system Helvetica Chimica Acta  2001 84:1778-1804  DOI:10.1002/1522-2675(20010613)84:6<1778::aid-hlca1778>3.3.co;2-v
  • Wippo, H., Reck, F., Kudick, R., Ramaseshan, M., Ceulemans, G., Bolli, M., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Part 11: Systems with shortened backbones: (D)-beta-ribopyranosyl-(4 '-> 3 ')- and (l)-alpha-lyxopyranosyl-(4 '-> 3 ')-oligonucleotides Bioorganic & Medicinal Chemistry  2001 9:2411-2428  DOI:10.1016/s0968-0896(01)00220-6  PMID:11553483
  • Eschenmoser, A., Krishnamurthy, R. Chemical etiology of nucleic acid structure Pure and Applied Chemistry  2000 72:343-345  DOI:10.1351/pac200072030343
  • Schoning, K. U., Scholz, P., Guntha, S., Wu, X., Krishnamurthy, R., Eschenmoser, A. Chemical etiology of nucleic acid structure: The alpha-threofuranosyl-(3 '-> 2 ') oligonucleotide system Science  2000 290:1347-1351  DOI:10.1126/science.290.5495.1347  PMID:11082060
  • Krishnamurthy, R., Guntha, S., Eschenmoser, A. Regioselective alpha-phosphorylation of aldoses in aqueous solution Angewandte Chemie-International Edition  2000 39:2281-2285  DOI:10.1002/1521-3773(20000703)39:13<2281::aid-anie2281>3.0.co;2-2  PMID:10941064
  • Beier, M., Reck, F., Wagner, T., Krishnamurthy, R., Eschenmoser, A. Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(2 '-> 4 ') oligonucleotides with RNA Science  1999 283:699-703  DOI:10.1126/science.283.5402.699  PMID:9924032
  • Krishnamurthy, R., Arrhenius, G., Eschenmoser, A. Formation of glycolaldehyde phosphate from glycolaldehyde in aqueous solution Origins of Life and Evolution of the Biosphere  1999 29:333-354  DOI:10.1023/a:1006698208873  PMID:10472624
  • Reck, F., Wippo, H., Kudick, R., Bolli, M., Ceulemans, G., Krishnamurthy, R., Eschenmoser, A. L-alpha-lyxopyranosyl (4 '-> 3 ') oligonucleotides: A base-pairing system containing a shortened backbone Organic Letters  1999 1:1531-1534  DOI:10.1021/ol990184q  PMID:10836020
  • Jungmann, O., Wippo, H., Stanek, M., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A. Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4 '-> 2 ') oligonucleotides Organic Letters  1999 1:1527-1530  DOI:10.1021/ol990183y  PMID:10836019
  • Krishnamurthy, R., Pitsch, S., Minton, M., Miculka, C., Windhab, N., Eschenmoser, A. Pyranosyl-RNA: Base pairing between homochiral oligonucleotide strands of opposite sense of chirality Angewandte Chemie-International Edition  1996 35:1537-1541  DOI:10.1002/anie.199615371
  • Pitsch, S., Krishnamurthy, R., Bolli, M., Wendeborn, S., Holzner, A., Minton, M., Lesueur, C., Schlonvogt, I., Jaun, B., Eschenmoser, A. Pyranosyl-RNA (‘p-RNA’): base-pairing selectivity and potential to replicate. Preliminary communication Helvetica Chimica Acta  1995 78:1621-1635  DOI:10.1002/hlca.19950780702
  • Otting, G., Billeter, M., Wuthrich, K., Roth, H. J., Leumann, C., Eschenmoser, A. Why pentose- and not hexose-​nucleic acids? Part IV. 'Homo-​DNA': 1H-​, 13C-​, 31P-​, and 15N-​NMR-​spectroscopic investigation of ddGlc(A-​A-​A-​A-​A-​T-​T-​T-​T-​T) in aqueous solution [Article in German] Helvetica Chimica Acta  1993 76:2701-2756  DOI:10.1002/hlca.19930760802