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Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

Academic Article
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Overview

authors

  • Singh, A. P.
  • Buscaglia, C. A.
  • Wang, Q.
  • Levay, A.
  • Nussenzweig, D. R.
  • Walker, J. R.
  • Winzeler, Elizabeth
  • Fujii, H.
  • Fontoura, B. M. A.
  • Nussenzweig, V.

publication date

  • 2007

journal

  • Cell  Journal

abstract

  • The liver stages of malaria are clinically silent but have a central role in the Plasmodium life cycle. Liver stages of the parasite containing thousands of merozoites grow inside hepatocytes for several days without triggering an inflammatory response. We show here that Plasmodium uses a PEXEL/VTS motif to introduce the circumsporozoite (CS) protein into the hepatocyte cytoplasm and a nuclear localization signal (NLS) to enter its nucleus. CS outcompetes NFkappaB nuclear import, thus downregulating the expression of many genes controlled by NFkappaB, including those involved in inflammation. CS also influences the expression of over one thousand host genes involved in diverse metabolic processes to create a favorable niche for the parasite growth. The presence of CS in the hepatocyte enhances parasite growth of the liver stages in vitro and in vivo. These findings have far reaching implications for drug and vaccine development against the liver stages of the malaria parasite.

subject areas

  • Amino Acid Motifs
  • Animals
  • Cell Nucleus
  • HeLa Cells
  • Hepatocytes
  • Humans
  • Karyopherins
  • Life Cycle Stages
  • Liver
  • Malaria
  • Mice
  • Mice, Inbred C57BL
  • Mutant Proteins
  • NF-kappa B
  • Nuclear Localization Signals
  • Plasmodium
  • Protein Transport
  • Protozoan Proteins
  • Rats
  • Rats, Sprague-Dawley
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2007.09.013

PubMed ID

  • 17981117
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Additional Document Info

start page

  • 492

end page

  • 504

volume

  • 131

issue

  • 3

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