recent publications

• academic article

  • Amar, A. P., Griffin, J. H., Zlokovic, B. V. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Frontiers in Cellular Neuroscience  2015 9:344  DOI:10.3389/fncel.2015.00344  PMID:26388732  PMCID:PMC4556986
  • Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C: biased for translation Blood  2015 125:2898-2907  DOI:10.1182/blood-2015-02-355974  PMID:25824691  PMCID:PMC4424414
  • Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. Cytoprotective-selective activated protein C therapy for ischaemic stroke Thrombosis and Haemostasis  2014 112:883-892  DOI:10.1160/th14-05-0448  PMID:25230930
  • Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., Cleveland, D. W., Zlokovic, B. V. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proceedings of the National Academy of Sciences of the United States of America  2014 111:E1035-E1042  DOI:10.1073/pnas.1401595111  PMID:24591593  PMCID:PMC3964055
  • Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., Zlokovic, B. V. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke  2013 44:3529-3536  DOI:10.1161/strokeaha.113.003350  PMID:24159062
  • Mosnier, L. O., Fernandez, J. A., Davis, T. P., Zlokovic, B. V., Griffin, J. H. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Journal of Thrombosis and Haemostasis  2013 11:2059-2062  DOI:10.1111/jth.12400  PMID:24034518  PMCID:PMC3850769
  • Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., Zlokovic, B. V. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Molecules and Diseases  2013 51:104-108  DOI:10.1016/j.bcmd2013.02.009  PMID:23541526
  • Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., Zlokovic, B. V. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Research  2013 1507:97-104  DOI:10.1016/j.brainres.2013.02.023  PMID:23438513  PMCID:PMC3739836
  • Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience  2013 33:6181-6190  DOI:10.1523/jneurosci.4491-12.2013  PMID:23554499
  • Wang, Y. M., Zhang, Z. G., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M., Zlokovic, B. V. An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke  2012 43:2444-2449  DOI:10.1161/strokeaha.112.658997  PMID:22811462  PMCID:PMC3429704
  • Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E., Davis, T. P. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Current Pharmaceutical Design  2012 18:4215-4222  DOI:10.2174/138161212802430413  PMID:22632606  PMCID:PMC3472038
  • Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Protein c anticoagulant and cytoprotective pathways International Journal of Hematology  2012 95:333-345  DOI:10.1007/s12185-012-1059-0  PMID:22477541  PMCID:PMC3413316
  • Zlokovic, B. V., Griffin, J. H. Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends in Neurosciences  2011 34:198-209  DOI:10.1016/j.tins.2011.01.005  PMID:21353711  PMCID:PMC3491752
  • Guo, H. A., Barrett, T. M., Zhong, Z. H., Fernandez, J. A., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Molecular Neurodegeneration  2011 6:13  DOI:10.1186/1750-1326-6-13  PMID:21291561  PMCID:PMC3042387
  • Zhong, Z. H., Wang, Y. M., Guo, H. A., Sagare, A., Fernandez, J. A., Bell, R. D., Barrett, T. M., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region Journal of Neuroscience  2010 30:15521-15534  DOI:10.1523/jneurosci.4437-10.2010  PMID:21084607  PMCID:PMC3012432
  • Fernandez, J. A., Heeb, M. J., Xu, X., Singh, I., Zlokovic, B. V., Griffin, J. H. Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica-The Hematology Journal  2009 94:1721-1731  DOI:10.3324/haematol.2009.009233  PMID:19815836  PMCID:PMC2791928
  • Zhong, Z. H., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., Zlokovic, A. B., Liu, T., et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Journal of Clinical Investigation  2009 119:3437-3449  DOI:10.1172/jci38476  PMID:19841542  PMCID:PMC2769191
  • Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry  2009 109:116-124  DOI:10.1111/j.1471-4159.2009.05921.x  PMID:19166505  PMCID:PMC2692505
  • Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience  2009 29:1119-1130  DOI:10.1111/j.1460-9568.2009.06664.x  PMID:19302148  PMCID:PMC2692517
  • Thiyagarajan, M., Fernandez, J. A., Lane, S. M., Griffin, J. H., Zlokovic, B. V. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 Journal of Neuroscience  2008 28:12788-12797  DOI:10.1523/jneurosci.3485-08.2008  PMID:19036971  PMCID:PMC2742231
  • Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. The cytoprotective protein C pathway Blood  2007 109:3161-3172  DOI:10.1182/blood-2006-09-003004  PMID:17110453
  • Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z. H., Wu, Z. H., Liu, D., Maggirwar, S. B., Deane, R., Fernandez, J. A., LaRue, B., Griffin, J. H., et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nature Medicine  2006 12:1278-1285  DOI:10.1038/nm1498  PMID:17072311
  • Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases  2006 36:211-216  DOI:10.1016/j,bcmd.2005.12.023  PMID:16464623
  • Zlokovic, B. V., Zhang, C. L., Liu, D., Fernandez, J., Griffin, J. H., Chopp, M. Functional recovery after embolic stroke in rodents by activated protein C Annals of Neurology  2005 58:474-477  DOI:10.1002/ana.20602  PMID:16130108
  • Liu, D., Cheng, T., Guo, H., Fernandez, J. A., Griffin, J. H., Song, X. M., Zlokovic, B. V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nature Medicine  2004 10:1379-1383  DOI:10.1038/nm1122  PMID:15516929
  • Griffin, J. H., Fernandez, J. A., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. Activated protein C and ischemic stroke Critical Care Medicine  2004 32:S247-S253  DOI:10.1097/01.cmm.0000126127.87484.2b  PMID:15118526
  • Guo, H., Liu, D., Gelbard, H., Cheng, T., Insalaco, R., Fernandez, J. A., Griffin, J. H., Zlokovic, B. V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron  2004 41:563-572  DOI:10.1016/s0896-6273(04)00019-4  PMID:14980205
  • Domotor, E., Benzakour, O., Griffin, J. H., Yule, D., Fukudome, K., Zlokovic, B. V. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood  2003 101:4797-4801  DOI:10.1182/blood-2002-12-3680  PMID:12586611
  • Fernandez, J. A., Xu, X., Liu, D., Zlokovic, B. V., Griffin, J. H. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Molecules and Diseases  2003 30:271-276  DOI:10.1016/s1079-9796(03)00034-2  PMID:12737945
  • Liu, D., Guo, H., Griffin, J. H., Fernandez, J. A., Zlokovic, B. V. Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation  2003 107:1791-1796  DOI:10.1161/01.cir.0000058460.34453.5a  PMID:12665496
  • Cheng, T., Liu, D., Griffin, J. H., Fernandez, J. A., Castellino, F., Rosen, E. D., Fukudome, K., Zlokovic, B. V. Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nature Medicine  2003 9:338-342  DOI:10.1038/nm826  PMID:12563316
  • Shibata, M., Kumar, S. R., Amar, A., Fernandez, J. A., Hofman, F., Griffin, J. H., Zlokovic, B. V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation  2001 103:1799-1805  PMID:11282913
  • Tabrizi, P., Wang, L., Seeds, N., McComb, J. G., Yamada, S., Griffin, J. H., Carmeliet, P., Weiss, M. H., Zlokovic, B. V. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background Arteriosclerosis, Thrombosis, and Vascular Biology  1999 19:2801-2806  PMID:10559029