recent publications
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academic article
- Amar, A. P., Griffin, J. H., Zlokovic, B. V. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Frontiers in Cellular Neuroscience 2015 9:344 DOI:10.3389/fncel.2015.00344 PMID:26388732 PMCID:PMC4556986
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C: biased for translation Blood 2015 125:2898-2907 DOI:10.1182/blood-2015-02-355974 PMID:25824691 PMCID:PMC4424414
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. Cytoprotective-selective activated protein C therapy for ischaemic stroke Thrombosis and Haemostasis 2014 112:883-892 DOI:10.1160/th14-05-0448 PMID:25230930
- Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., Cleveland, D. W., Zlokovic, B. V. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proceedings of the National Academy of Sciences of the United States of America 2014 111:E1035-E1042 DOI:10.1073/pnas.1401595111 PMID:24591593 PMCID:PMC3964055
- Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., Zlokovic, B. V. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke 2013 44:3529-3536 DOI:10.1161/strokeaha.113.003350 PMID:24159062
- Mosnier, L. O., Fernandez, J. A., Davis, T. P., Zlokovic, B. V., Griffin, J. H. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Journal of Thrombosis and Haemostasis 2013 11:2059-2062 DOI:10.1111/jth.12400 PMID:24034518 PMCID:PMC3850769
- Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., Zlokovic, B. V. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Molecules and Diseases 2013 51:104-108 DOI:10.1016/j.bcmd2013.02.009 PMID:23541526
- Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., Zlokovic, B. V. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Research 2013 1507:97-104 DOI:10.1016/j.brainres.2013.02.023 PMID:23438513 PMCID:PMC3739836
- Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience 2013 33:6181-6190 DOI:10.1523/jneurosci.4491-12.2013 PMID:23554499
- Wang, Y. M., Zhang, Z. G., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M., Zlokovic, B. V. An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke 2012 43:2444-2449 DOI:10.1161/strokeaha.112.658997 PMID:22811462 PMCID:PMC3429704
- Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E., Davis, T. P. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Current Pharmaceutical Design 2012 18:4215-4222 DOI:10.2174/138161212802430413 PMID:22632606 PMCID:PMC3472038
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Protein c anticoagulant and cytoprotective pathways International Journal of Hematology 2012 95:333-345 DOI:10.1007/s12185-012-1059-0 PMID:22477541 PMCID:PMC3413316
- Zlokovic, B. V., Griffin, J. H. Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends in Neurosciences 2011 34:198-209 DOI:10.1016/j.tins.2011.01.005 PMID:21353711 PMCID:PMC3491752
- Guo, H. A., Barrett, T. M., Zhong, Z. H., Fernandez, J. A., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Molecular Neurodegeneration 2011 6:13 DOI:10.1186/1750-1326-6-13 PMID:21291561 PMCID:PMC3042387
- Zhong, Z. H., Wang, Y. M., Guo, H. A., Sagare, A., Fernandez, J. A., Bell, R. D., Barrett, T. M., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region Journal of Neuroscience 2010 30:15521-15534 DOI:10.1523/jneurosci.4437-10.2010 PMID:21084607 PMCID:PMC3012432
- Fernandez, J. A., Heeb, M. J., Xu, X., Singh, I., Zlokovic, B. V., Griffin, J. H. Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica-The Hematology Journal 2009 94:1721-1731 DOI:10.3324/haematol.2009.009233 PMID:19815836 PMCID:PMC2791928
- Zhong, Z. H., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., Zlokovic, A. B., Liu, T., et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Journal of Clinical Investigation 2009 119:3437-3449 DOI:10.1172/jci38476 PMID:19841542 PMCID:PMC2769191
- Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry 2009 109:116-124 DOI:10.1111/j.1471-4159.2009.05921.x PMID:19166505 PMCID:PMC2692505
- Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience 2009 29:1119-1130 DOI:10.1111/j.1460-9568.2009.06664.x PMID:19302148 PMCID:PMC2692517
- Thiyagarajan, M., Fernandez, J. A., Lane, S. M., Griffin, J. H., Zlokovic, B. V. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 Journal of Neuroscience 2008 28:12788-12797 DOI:10.1523/jneurosci.3485-08.2008 PMID:19036971 PMCID:PMC2742231
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. The cytoprotective protein C pathway Blood 2007 109:3161-3172 DOI:10.1182/blood-2006-09-003004 PMID:17110453
- Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z. H., Wu, Z. H., Liu, D., Maggirwar, S. B., Deane, R., Fernandez, J. A., LaRue, B., Griffin, J. H., et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nature Medicine 2006 12:1278-1285 DOI:10.1038/nm1498 PMID:17072311
- Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases 2006 36:211-216 DOI:10.1016/j,bcmd.2005.12.023 PMID:16464623
- Zlokovic, B. V., Zhang, C. L., Liu, D., Fernandez, J., Griffin, J. H., Chopp, M. Functional recovery after embolic stroke in rodents by activated protein C Annals of Neurology 2005 58:474-477 DOI:10.1002/ana.20602 PMID:16130108
- Liu, D., Cheng, T., Guo, H., Fernandez, J. A., Griffin, J. H., Song, X. M., Zlokovic, B. V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nature Medicine 2004 10:1379-1383 DOI:10.1038/nm1122 PMID:15516929
- Griffin, J. H., Fernandez, J. A., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. Activated protein C and ischemic stroke Critical Care Medicine 2004 32:S247-S253 DOI:10.1097/01.cmm.0000126127.87484.2b PMID:15118526
- Guo, H., Liu, D., Gelbard, H., Cheng, T., Insalaco, R., Fernandez, J. A., Griffin, J. H., Zlokovic, B. V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron 2004 41:563-572 DOI:10.1016/s0896-6273(04)00019-4 PMID:14980205
- Domotor, E., Benzakour, O., Griffin, J. H., Yule, D., Fukudome, K., Zlokovic, B. V. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood 2003 101:4797-4801 DOI:10.1182/blood-2002-12-3680 PMID:12586611
- Fernandez, J. A., Xu, X., Liu, D., Zlokovic, B. V., Griffin, J. H. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Molecules and Diseases 2003 30:271-276 DOI:10.1016/s1079-9796(03)00034-2 PMID:12737945
- Liu, D., Guo, H., Griffin, J. H., Fernandez, J. A., Zlokovic, B. V. Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation 2003 107:1791-1796 DOI:10.1161/01.cir.0000058460.34453.5a PMID:12665496
- Cheng, T., Liu, D., Griffin, J. H., Fernandez, J. A., Castellino, F., Rosen, E. D., Fukudome, K., Zlokovic, B. V. Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nature Medicine 2003 9:338-342 DOI:10.1038/nm826 PMID:12563316
- Shibata, M., Kumar, S. R., Amar, A., Fernandez, J. A., Hofman, F., Griffin, J. H., Zlokovic, B. V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation 2001 103:1799-1805 PMID:11282913
- Tabrizi, P., Wang, L., Seeds, N., McComb, J. G., Yamada, S., Griffin, J. H., Carmeliet, P., Weiss, M. H., Zlokovic, B. V. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19:2801-2806 PMID:10559029