recent publications
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academic article
- Kong, L., Kadam, R. U., Giang, E., Ruwona, T. B., Nieusma, T., Culhane, J. C., Stanfield, R. L., Dawson, P. E., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526 Journal of Molecular Biology 2015 427:2617-2628 DOI:10.1016/j.jmb.2015.06.012 PMID:26135247 PMCID:PMC4523428
- He, L., Cheng, Y., Kong, L., Azadnia, P., Giang, E., Kim, J., Wood, M. R., Wilson, I. A., Law, M., Zhu, J. Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding Scientific Reports 2015 5:12501 DOI:10.1038/srep12501 PMID:26238798 PMCID:PMC4533164
- Kong, L., Jackson, K. N., Wilson, I. A., Law, M. Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design Current Opinion in Virology 2015 11:148-157 DOI:10.1016/j.coviro.2015.04.001 PMID:25932568 PMCID:PMC4507806
- Kong, L., Wilson, I. A., Kwong, P. D. Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262 Proteins-Structure Function and Bioinformatics 2015 83:590-596 DOI:10.1002/prot.24747 PMID:25546301 PMCID:PMC4409329
- Kong, L., Torrents de la Peña, A., Deller, M. C., Garces, F., Sliepen, K., Hua, Y., Stanfield, R. L., Sanders, R. W., Wilson, I. A. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Acta Crystallographica Section D-Biological Crystallography 2015 71:2099-2108 DOI:10.1107/s1399004715013917 PMID:26457433 PMCID:PMC4601371
- Doores, K. J., Kong, L., Krumm, S. A., Le, K. M., Sok, D., Laserson, U., Garces, F., Poignard, P., Wilson, I. A., Burton, D. R. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope Journal of Virology 2015 89:1105-1118 DOI:10.1128/jvi02905-14 PMID:25378488 PMCID:PMC4300629
- Ingale, J., Tran, K., Kong, L., Dey, B., McKee, K., Schief, W., Kwong, P. D., Mascola, J. R., Wyatt, R. T. Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies Journal of Virology 2014 88:14002-14016 DOI:10.1128/jvi.02614-14 PMID:25253346 PMCID:PMC4249138
- Garces, F., Sok, D., Kong, L., McBride, R., Kim, H. J., Saye-Francisco, K. F., Julien, J. P., Hua, Y., Cupo, A., Moore, J. P., Paulson, J. C., Ward, A. B., et al. Structural evolution of glycan recognition by a family of potent HIV antibodies Cell 2014 159:69-79 DOI:10.1016/j.cell.2014.09.009 PMID:25259921 PMCID:PMC4278586
- Grover, R. K., Zhu, X., Nieusma, T., Jones, T., Boero, I., MacLeod, A. S., Mark, A., Niessen, S., Kim, H. J., Kong, L., Assad-Garcia, N., Kwon, K., et al. A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union Science 2014 343:656-661 DOI:10.1126/science.1246135 PMID:24503852 PMCID:PMC3987992
- Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., Wilson, I. A., Law, M. Hepatitis C virus E2 envelope glycoprotein core structure Science 2013 342:1090-1094 DOI:10.1126/science.1243876 PMID:24288331 PMCID:PMC3954638
- Schiffner, T., Kong, L., Duncan, C. J. A., Back, J. W., Benschop, J. J., Shen, X., Huang, P. S., Stewart-Jones, G. B., DeStefano, J., Seaman, M. S., Tomaras, G. D., Montefiori, D. C., et al. Immune Focusing and Enhanced Neutralization Induced by HIV-1 gp140 Chemical Cross-Linking Journal of Virology 2013 87:10163-10172 DOI:10.1128/jvi.01161-13 PMID:23843636 PMCID:PMC3754013
- Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology 2013 20:796-803 DOI:10.1038/nsmb.2594 PMID:23708606 PMCID:PMC3823233
- Kong, L., Giang, E., Nieusma, T., Robbins, J. B., Deller, M. C., Stanfield, R. L., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33 Journal of Virology 2012 86:13085-13088 DOI:10.1128/jvi.01939-12 PMID:22973046 PMCID:PMC3497658
- Kong, L., Giang, E., Robbins, J. B., Stanfield, R. L., Burton, D. R., Wilson, I. A., Law, M. Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1 Proceedings of the National Academy of Sciences of the United States of America 2012 109:9499-9504 DOI:10.1073/pnas.1202924109 PMID:22623528 PMCID:PMC3386053
- Pancera, M., Majeed, S., Ban, Y. E. A., Chen, L., Huang, C. C., Kong, L., Kwon, Y. D., Stuckey, J., Zhou, T. Q., Robinson, J. E., Schief, W. R., Sodroski, J., et al. Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility Proceedings of the National Academy of Sciences of the United States of America 2010 107:1166-1171 DOI:10.1073/pnas.0911004107 PMID:20080564 PMCID:PMC2824281
- Abruzzo, G. K., Gill, C. J., Flattery, A. M., Kong, L., Leighton, C., Smith, J. G., Pikounis, V. B., Bartizal, K., Rosen, H. Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice Antimicrobial Agents and Chemotherapy 2000 44:2310-2318 DOI:10.1128/aac.44.9.2310-2318.2000 PMID:10952573
- Abruzzo, G. K., Flattery, A. M., Gill, C. J., Kong, L., Smith, J. G., Pikounis, V. B., Balkovec, J. M., Bouffard, A. F., Dropinski, J. F., Rosen, H., Kropp, H., Bartizal, K. Evaluation of the echinocandin antifungal mk-0991 (l-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis Antimicrobial Agents and Chemotherapy 1997 41:2333-2338 PMID:9371329 PMCID:PMC164124