recent publications

• academic article

  • Kong, L., Kadam, R. U., Giang, E., Ruwona, T. B., Nieusma, T., Culhane, J. C., Stanfield, R. L., Dawson, P. E., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526 Journal of Molecular Biology  2015 427:2617-2628  DOI:10.1016/j.jmb.2015.06.012  PMID:26135247  PMCID:PMC4523428
  • He, L., Cheng, Y., Kong, L., Azadnia, P., Giang, E., Kim, J., Wood, M. R., Wilson, I. A., Law, M., Zhu, J. Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding Scientific Reports  2015 5:12501  DOI:10.1038/srep12501  PMID:26238798  PMCID:PMC4533164
  • Kong, L., Jackson, K. N., Wilson, I. A., Law, M. Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design Current Opinion in Virology  2015 11:148-157  DOI:10.1016/j.coviro.2015.04.001  PMID:25932568  PMCID:PMC4507806
  • Kong, L., Wilson, I. A., Kwong, P. D. Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262 Proteins-Structure Function and Bioinformatics  2015 83:590-596  DOI:10.1002/prot.24747  PMID:25546301  PMCID:PMC4409329
  • Kong, L., Torrents de la Peña, A., Deller, M. C., Garces, F., Sliepen, K., Hua, Y., Stanfield, R. L., Sanders, R. W., Wilson, I. A. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Acta Crystallographica Section D-Biological Crystallography  2015 71:2099-2108  DOI:10.1107/s1399004715013917  PMID:26457433  PMCID:PMC4601371
  • Doores, K. J., Kong, L., Krumm, S. A., Le, K. M., Sok, D., Laserson, U., Garces, F., Poignard, P., Wilson, I. A., Burton, D. R. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope Journal of Virology  2015 89:1105-1118  DOI:10.1128/jvi02905-14  PMID:25378488  PMCID:PMC4300629
  • Ingale, J., Tran, K., Kong, L., Dey, B., McKee, K., Schief, W., Kwong, P. D., Mascola, J. R., Wyatt, R. T. Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies Journal of Virology  2014 88:14002-14016  DOI:10.1128/jvi.02614-14  PMID:25253346  PMCID:PMC4249138
  • Garces, F., Sok, D., Kong, L., McBride, R., Kim, H. J., Saye-Francisco, K. F., Julien, J. P., Hua, Y., Cupo, A., Moore, J. P., Paulson, J. C., Ward, A. B., et al. Structural evolution of glycan recognition by a family of potent HIV antibodies Cell  2014 159:69-79  DOI:10.1016/j.cell.2014.09.009  PMID:25259921  PMCID:PMC4278586
  • Grover, R. K., Zhu, X., Nieusma, T., Jones, T., Boero, I., MacLeod, A. S., Mark, A., Niessen, S., Kim, H. J., Kong, L., Assad-Garcia, N., Kwon, K., et al. A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union Science  2014 343:656-661  DOI:10.1126/science.1246135  PMID:24503852  PMCID:PMC3987992
  • Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., Wilson, I. A., Law, M. Hepatitis C virus E2 envelope glycoprotein core structure Science  2013 342:1090-1094  DOI:10.1126/science.1243876  PMID:24288331  PMCID:PMC3954638
  • Schiffner, T., Kong, L., Duncan, C. J. A., Back, J. W., Benschop, J. J., Shen, X., Huang, P. S., Stewart-Jones, G. B., DeStefano, J., Seaman, M. S., Tomaras, G. D., Montefiori, D. C., et al. Immune Focusing and Enhanced Neutralization Induced by HIV-1 gp140 Chemical Cross-Linking Journal of Virology  2013 87:10163-10172  DOI:10.1128/jvi.01161-13  PMID:23843636  PMCID:PMC3754013
  • Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology  2013 20:796-803  DOI:10.1038/nsmb.2594  PMID:23708606  PMCID:PMC3823233
  • Kong, L., Giang, E., Nieusma, T., Robbins, J. B., Deller, M. C., Stanfield, R. L., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33 Journal of Virology  2012 86:13085-13088  DOI:10.1128/jvi.01939-12  PMID:22973046  PMCID:PMC3497658
  • Kong, L., Giang, E., Robbins, J. B., Stanfield, R. L., Burton, D. R., Wilson, I. A., Law, M. Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1 Proceedings of the National Academy of Sciences of the United States of America  2012 109:9499-9504  DOI:10.1073/pnas.1202924109  PMID:22623528  PMCID:PMC3386053
  • Pancera, M., Majeed, S., Ban, Y. E. A., Chen, L., Huang, C. C., Kong, L., Kwon, Y. D., Stuckey, J., Zhou, T. Q., Robinson, J. E., Schief, W. R., Sodroski, J., et al. Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility Proceedings of the National Academy of Sciences of the United States of America  2010 107:1166-1171  DOI:10.1073/pnas.0911004107  PMID:20080564  PMCID:PMC2824281
  • Abruzzo, G. K., Gill, C. J., Flattery, A. M., Kong, L., Leighton, C., Smith, J. G., Pikounis, V. B., Bartizal, K., Rosen, H. Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice Antimicrobial Agents and Chemotherapy  2000 44:2310-2318  DOI:10.1128/aac.44.9.2310-2318.2000  PMID:10952573
  • Abruzzo, G. K., Flattery, A. M., Gill, C. J., Kong, L., Smith, J. G., Pikounis, V. B., Balkovec, J. M., Bouffard, A. F., Dropinski, J. F., Rosen, H., Kropp, H., Bartizal, K. Evaluation of the echinocandin antifungal mk-0991 (l-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis Antimicrobial Agents and Chemotherapy  1997 41:2333-2338  PMID:9371329  PMCID:PMC164124