recent publications

• academic article

  • Sundheim, O., Vagbo, C. B., Bjoras, M., Sousa, M. M. L., Talstad, V., Aas, P. A., Drablos, F., Krokan, H. E., Tainer, J. A., Slupphaug, G. Human abh3 structure and key residues for oxidative demethylation to reverse DNA/rna damage EMBO Journal  2006 25:3389-3397  DOI:10.1038/sj.emboj.7601219  PMID:16858410  PMCID:PMC1523172
  • Parikh, S. S., Walcher, G., Jones, G. D., Slupphaug, G., Krokan, H. E., Blackburn, G. M., Tainer, J. A. Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Proceedings of the National Academy of Sciences of the United States of America  2000 97:5083-5088  DOI:10.1073/pnas.97.10.5083  PMID:10805771
  • Parikh, S. S., Mol, C. D., Slupphaug, G., Bharati, S., Krokan, H. E., Tainer, J. A. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA EMBO Journal  1998 17:5214-5226  DOI:10.1093/emboj/17.17.5214  PMID:9724657  PMCID:PMC1170849
  • Slupphaug, G., Mol, C. D., Kavli, B., Arvai, A. S., Krokan, H. E., Tainer, J. A. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA Nature  1996 384:87-92  DOI:10.1038/384087a0  PMID:8900285
  • Kavli, B., Slupphaug, G., Mol, C. D., Arvai, A. S., Petersen, S. B., Tainer, J. A., Krokan, H. E. Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase EMBO Journal  1996 15:3442-3447  PMID:8670846  PMCID:PMC451908
  • Mol, C. D., Arvai, A. S., Sanderson, R. J., Slupphaug, G., Kavli, B., Krokan, H. E., Mosbaugh, D. W., Tainer, J. A. Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA Cell  1995 82:701-708  DOI:10.1016/0092-8674(95)90467-0  PMID:7671300
  • Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H. E., Tainer, J. A. Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis Cell  1995 80:869-878  DOI:10.1016/0092-8674(95)90290-2  PMID:7697717