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Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and african americans

Academic Article
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Overview

authors

  • Schork, Nicholas
  • Chakravarti, A.
  • Thiel, B.
  • Fornage, M.
  • Jacob, H. J.
  • Cai, R.
  • Rotimi, C. N.
  • Cooper, R. S.
  • Weder, A. B.

publication date

  • June 2000

journal

  • American Journal of Hypertension  Journal

abstract

  • Population-based candidate gene association analyses are becoming increasingly popular as a result of a greater number of genes and gene polymorphisms having been identified for which some functional information is available. Because many biochemical and physiologic systems impact blood pressure regulation and hypertension susceptibility, many of these identified genes and polymorphisms are candidates for population-level association studies involving blood pressure levels or hypertension status. Recent studies have suggested that the alpha-adducin gene may harbor polymorphisms that influence blood pressure level. Therefore, we embarked on a study to test one such polymorphism in two large US samples: one from an urban African American population (Maywood, IL) and another from a rural white population (Tecumseh, MI). We used both family-based association tests and tests that consider the impact of additional measured factors beyond adducin gene variation on blood pressure levels. We found no evidence for a significant effect of the chosen adducin polymorphism on blood pressure variation in either sample. We also found no association between Adducin genotypes and antihypertensive use. These facts, together with similar findings in companion studies, suggest that the alpha-adducin gene polymorphism does not have a pronounced effect on blood pressure variation in the populations studied. This does not suggest, however, that the alpha-adducin gene does not have a role in blood pressure regulation and hypertension susceptibility.

subject areas

  • Adult
  • African Continental Ancestry Group
  • Alleles
  • Blood Pressure
  • Calmodulin-Binding Proteins
  • Circadian Rhythm
  • Cytoskeletal Proteins
  • DNA
  • DNA Primers
  • European Continental Ancestry Group
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Hypertension
  • Illinois
  • Michigan
  • Polymorphism, Genetic
  • Rural Population
  • Urban Population
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Research

keywords

  • adducin
  • blood pressure
  • genetics
  • heredity
  • hypertension
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Identity

International Standard Serial Number (ISSN)

  • 0895-7061

Digital Object Identifier (DOI)

  • 10.1016/s0895-7061(00)00237-5

PubMed ID

  • 10912755
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Additional Document Info

start page

  • 693

end page

  • 698

volume

  • 13

issue

  • 6

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