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CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development

Academic Article
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Overview

authors

  • Petrie, Howard
  • Strasser, A.
  • Harris, A. W.
  • Hugo, P.
  • Shortman, K.

publication date

  • August 1993

journal

  • Journal of Immunology  Journal

abstract

  • Two primary types of TCR-alpha/beta+ T cells are found in the peripheral lymphoid system; CD4+8- T cells, with MHC-class II restricted TCR, and CD4-8+ T cells, which are MHC-class I restricted. Both lineages develop in the thymus from a series of common precursors. However, the precise stage at which they diverge, and the combination of factors that regulates such divergence, are not well defined. The up-regulation of CD3/TCR to high mature levels is thought to be an early event associated with positive selection for self-MHC recognition. Using purified cells from bcl-2 transgenic mice in order to overcome the limitations imposed by cell death on normal thymocytes, we find that a minor subset of CD4+8+ thymocytes expressing high levels of CD3/TCR gives rise to both CD4+8- and CD4-8+ mature cells upon intrathymic transplantation, but only to CD4-8+ in culture. Thus, in addition to demonstrating the dual lineage potential of this subset, these findings show that additional post-selection processing events are required for the production of mature thymocytes, and that CD4+8- and CD4-8+ subsets differ in the types of processing required.

subject areas

  • Animals
  • Antigens, CD3
  • Antigens, CD8
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Female
  • Flow Cytometry
  • Immunophenotyping
  • Male
  • Mice
  • Mice, Transgenic
  • T-Lymphocyte Subsets
  • Thymus Gland
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 8101540
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Additional Document Info

start page

  • 1273

end page

  • 1279

volume

  • 151

issue

  • 3

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