recent publications

• academic article

  • von Drygalski, A., Bhat, V., Gale, A. J., Burnier, L., Cramer, T. J., Griffin, J. H., Mosnier, L. O. An engineered Factor Va prevents bleeding induced by anticoagulant wt activated protein C PLoS One  2014 9:e104304  DOI:10.1371/journal.pone.0104304  PMID:25127130  PMCID:PMC4134195
  • von Drygalski, A., Cramer, T. J., Bhat, V., Griffin, J. H., Gale, A. J., Mosnier, L. O. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Journal of Thrombosis and Haemostasis  2014 12:363-372  DOI:10.1111/jth.12489  PMID:24818532  PMCID:PMC4161283
  • Cramer, T. J., Gale, A. J. The anticoagulant function of coagulation factor v Thrombosis and Haemostasis  2012 107:15-21  DOI:10.1160/th11-06-0431  PMID:22116556
  • Cramer, T. J., Gale, A. J. Function of the activated protein c (apc) autolysis loop in activated fviii inactivation British Journal of Haematology  2011 153:644-654  DOI:10.1111/j.1365-2141.2011.08657.x  PMID:21457218  PMCID:PMC3091999
  • Cramer, T. J., Griffin, J. H., Gale, A. J. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va Pathophysiology of Haemostasis and Thrombosis  2010 37:17-23  DOI:10.1159/000315141  PMID:20501981  PMCID:PMC2974842
  • Gale, A. J., Cramer, T. J., Rozenshteyn, D., Cruz, J. R. Detailed mechanisms of the inactivation of factor viiia by activated protein c in the presence of its cofactors, protein s and factor v Journal of Biological Chemistry  2008 283:16355-16362  DOI:10.1074/jbc.M708985200  PMID:18424440  PMCID:PMC2423237