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Platelets mediate cytotoxic T lymphocyte-induced liver damage

Academic Article
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Overview

authors

  • Iannacone, M.
  • Sitia, G.
  • Isogawa, Masanori
  • Marchese, P.
  • Castro, M. G.
  • Lowenstein, P. R.
  • Chisari, Francis
  • Ruggeri, Zaverio
  • Guidotti, Luca

publication date

  • November 2005

journal

  • Nature Medicine  Journal

abstract

  • We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

subject areas

  • Animals
  • Blood Platelets
  • Cell Count
  • Cytotoxicity, Immunologic
  • Disease Models, Animal
  • Hepatitis B
  • Hepatitis B virus
  • Liver
  • Liver Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Platelet Activation
  • Severity of Illness Index
  • T-Lymphocytes, Cytotoxic
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Identity

PubMed Central ID

  • PMC2908083

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm1317

PubMed ID

  • 16258538
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Additional Document Info

start page

  • 1167

end page

  • 1169

volume

  • 11

issue

  • 11

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