Pd(0)/PR(3)-catalzed intermolecular arylation of sp(3) C-H bonds

Academic Article
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publication date

  • 2009

abstract

  • Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR(3)/ArI. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest.