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Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat

Academic Article
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Overview

authors

  • Vaccarino, F. J.
  • Amalric, M.
  • Swerdlow, N. R.
  • Koob, George

publication date

  • 1986

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The effects of pharmacological blockade of dopamine (DA) receptors or 6-OHDA lesions of mesolimbic DA fibers on the locomotor-activating properties of systemic amphetamine (0.35 mg/kg) and heroin (0.5 mg/kg) were examined. Pharmacological blockade of DA receptors or lesions of mesolimbic DA neurons blocked amphetamine but not heroin-induced locomotion. These results show that the opiate receptors essential for opiate-induced locomotor activation are not located on mesolimbic DA neurons. It appears that DA plays a primary role in stimulant-induced locomotion, but may have only a secondary role in opiate locomotion.

subject areas

  • Amphetamine
  • Animals
  • Dopamine Antagonists
  • Flupenthixol
  • Heroin
  • Hydroxydopamines
  • Limbic System
  • Male
  • Motor Activity
  • Narcotic Antagonists
  • Oxidopamine
  • Rats
  • Rats, Inbred Strains
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(86)90045-6

PubMed ID

  • 3080760
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Additional Document Info

start page

  • 61

end page

  • 65

volume

  • 24

issue

  • 1

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