recent publications
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academic article
- Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., et al. Loss of t cell and b cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in gimap5-deficient mice Journal of Immunology 2010 184:3743-3754 DOI:10.4049/jimmunol.0903164 PMID:20190135 PMCID:PMC4395861
- Barnes, M. J., Krebs, P., Harris, N., Eidenschenk, C., Gonzalez-Quintial, R., Arnold, C. N., Crozat, K., Sovath, S., Moresco, E. M., Theofilopoulos, A. N., Beutler, B., Hoebe, K. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery PLoS Biology 2009 7:e1000051 DOI:10.1371/journal.pbio.1000051 PMID:19260764 PMCID:PMC2650725
- Croker, B. A., Lawson, B. R., Rutschmann, S., Berger, M., Eidenschenk, C., Blasius, A. L., Moresco, E. M. Y., Sovath, S., Cengia, L., Shultz, L. D., Theofilopoulos, A. N., Pettersson, S., et al. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger Proceedings of the National Academy of Sciences of the United States of America 2008 105:15028-15033 DOI:10.1073/pnas.0806619105 PMID:18806225 PMCID:PMC2567487
- Croker, B., Crozat, K., Berger, M., Xia, Y., Sovath, S., Schaffer, L., Eleftherianos, I., Imler, J. L., Beutler, B. Atp-sensitive potassium channels mediate survival during infection in mammals and insects Nature Genetics 2007 39:1453-1460 DOI:10.1038/ng.2007.25 PMID:18026101
- Crozat, K., Hoebe, K., Ugolini, S., Hong, N. A., Janssen, E., Rutschmann, S., Mudd, S., Sovath, S., Vivier, E., Beutler, B. Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis Journal of Experimental Medicine 2007 204:853-863 DOI:10.1084/jem.20062447 PMID:17420270 PMCID:PMC2118559
- Jiang, Z. F., Georgel, P., Li, C. L., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S., Wilson, I. A., Olson, A. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Proceedings of the National Academy of Sciences of the United States of America 2006 103:10961-10966 DOI:10.1073/pnas.0603804103 PMID:16832055 PMCID:PMC1544157
- Huber, M., Kalis, C., Keck, S., Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M. A. R-form lps, the master key to the activation of tlr4/md-2-positive cells European Journal of Immunology 2006 36:701-711 DOI:10.1002/eji.200535593 PMID:16506285
- Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology 2006 7:156-164 DOI:10.1038/ni1297 PMID:16415873
- Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity 2005 73:4512-4521 DOI:10.1128/iai.73.8.4512-4521.2005 PMID:16040962
- Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., Beutler, B. Cd14 is required for myd88-independent lps signaling Nature Immunology 2005 6:565-570 DOI:10.1038/ni1207 PMID:15895089
- Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature 2005 433:523-527 DOI:10.1038/nature03253 PMID:15690042
- Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America 2004 101:3516-3521 DOI:10.1073/pnas.0400525101 PMID:14993594 PMCID:PMC373494
- Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics 2004 166:331-340 DOI:10.1534/genetics.166.1.331 PMID:15020428
- Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature 2003 424:743-748 DOI:10.1038/nature01889 PMID:12872135