recent publications

• academic article

  • Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., et al. Loss of t cell and b cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in gimap5-deficient mice Journal of Immunology  2010 184:3743-3754  DOI:10.4049/jimmunol.0903164  PMID:20190135  PMCID:PMC4395861
  • Barnes, M. J., Krebs, P., Harris, N., Eidenschenk, C., Gonzalez-Quintial, R., Arnold, C. N., Crozat, K., Sovath, S., Moresco, E. M., Theofilopoulos, A. N., Beutler, B., Hoebe, K. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery PLoS Biology  2009 7:e1000051  DOI:10.1371/journal.pbio.1000051  PMID:19260764  PMCID:PMC2650725
  • Croker, B. A., Lawson, B. R., Rutschmann, S., Berger, M., Eidenschenk, C., Blasius, A. L., Moresco, E. M. Y., Sovath, S., Cengia, L., Shultz, L. D., Theofilopoulos, A. N., Pettersson, S., et al. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger Proceedings of the National Academy of Sciences of the United States of America  2008 105:15028-15033  DOI:10.1073/pnas.0806619105  PMID:18806225  PMCID:PMC2567487
  • Croker, B., Crozat, K., Berger, M., Xia, Y., Sovath, S., Schaffer, L., Eleftherianos, I., Imler, J. L., Beutler, B. Atp-sensitive potassium channels mediate survival during infection in mammals and insects Nature Genetics  2007 39:1453-1460  DOI:10.1038/ng.2007.25  PMID:18026101
  • Crozat, K., Hoebe, K., Ugolini, S., Hong, N. A., Janssen, E., Rutschmann, S., Mudd, S., Sovath, S., Vivier, E., Beutler, B. Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis Journal of Experimental Medicine  2007 204:853-863  DOI:10.1084/jem.20062447  PMID:17420270  PMCID:PMC2118559
  • Jiang, Z. F., Georgel, P., Li, C. L., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S., Wilson, I. A., Olson, A. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Proceedings of the National Academy of Sciences of the United States of America  2006 103:10961-10966  DOI:10.1073/pnas.0603804103  PMID:16832055  PMCID:PMC1544157
  • Huber, M., Kalis, C., Keck, S., Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M. A. R-form lps, the master key to the activation of tlr4/md-2-positive cells European Journal of Immunology  2006 36:701-711  DOI:10.1002/eji.200535593  PMID:16506285
  • Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology  2006 7:156-164  DOI:10.1038/ni1297  PMID:16415873
  • Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity  2005 73:4512-4521  DOI:10.1128/iai.73.8.4512-4521.2005  PMID:16040962
  • Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., Beutler, B. Cd14 is required for myd88-independent lps signaling Nature Immunology  2005 6:565-570  DOI:10.1038/ni1207  PMID:15895089
  • Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature  2005 433:523-527  DOI:10.1038/nature03253  PMID:15690042
  • Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America  2004 101:3516-3521  DOI:10.1073/pnas.0400525101  PMID:14993594  PMCID:PMC373494
  • Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics  2004 166:331-340  DOI:10.1534/genetics.166.1.331  PMID:15020428
  • Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature  2003 424:743-748  DOI:10.1038/nature01889  PMID:12872135