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Cell surface biology mediated by low affinity multivalent protein-glycan interactions

Academic Article
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Overview

authors

  • Collins, B. E.
  • Paulson, James

publication date

  • December 2004

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • Glycan-binding proteins mediate diverse aspects of cell biology including pathogen recognition of host cells, cell trafficking, endocytosis and modulation of cell signaling. This is accomplished despite the intrinsic low affinity for their ligands through multivalent interactions that increase effective affinity and adhesive force. Recent successes in the rational design of high-affinity ligands for glycan-binding proteins offer the promise to create well-defined tools for exploring the structure and functions of this class of receptors.

subject areas

  • Animals
  • Bacterial Proteins
  • Cell Adhesion
  • Cell Communication
  • Cell Movement
  • Ligands
  • Polysaccharides
  • Protein Binding
  • Receptors, Cell Surface
  • Viral Proteins
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2004.10.004

PubMed ID

  • 15556405
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Additional Document Info

start page

  • 617

end page

  • 625

volume

  • 8

issue

  • 6

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