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Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning

Academic Article
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Overview

authors

  • Yu, D.
  • Keene, A. C.
  • Srivatsan, A.
  • Waddell, S.
  • Davis, Ronald

publication date

  • December 2005

journal

  • Cell  Journal

abstract

  • Formation of normal olfactory memory requires the expression of the wild-type amnesiac gene in the dorsal paired medial (DPM) neurons. Imaging the activity in the processes of DPM neurons revealed that the neurons respond when the fly is stimulated with electric shock or with any odor that was tested. Pairing odor and electric-shock stimulation increases odor-evoked calcium signals and synaptic release from DPM neurons. These memory traces form in only one of the two branches of the DPM neuron process. Moreover, trace formation requires the expression of the wild-type amnesiac gene in the DPM neurons. The cellular memory traces first appear at 30 min after conditioning and persist for at least 1 hr, a time window during which DPM neuron synaptic transmission is required for normal memory. DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition.

subject areas

  • Animals
  • Calcium
  • Conditioning, Classical
  • Drosophila Proteins
  • Drosophila melanogaster
  • Electric Stimulation
  • Memory
  • Neurons
  • Neuropeptides
  • Odorants
  • Smell
  • Synaptic Transmission
  • Time Factors
  • Transgenes
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.09.037

PubMed ID

  • 16325586
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Additional Document Info

start page

  • 945

end page

  • 957

volume

  • 123

issue

  • 5

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