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Selective d-1 and d-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat

Academic Article
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Overview

authors

  • Amalric, M.
  • Koob, George
  • Creese, I.
  • Swerdlow, N. R.

publication date

  • November 1986

journal

  • Life Sciences  Journal

abstract

  • The dopamine receptor antagonists SCH 23390 and spiperone show highly selective in vitro affinity for D-1 and D-2 dopamine receptor subtypes, respectively. We studied the effects of these selective antagonists on the supersensitive locomotor response to apomorphine in rats following 6- hydroxydopamine (6OHDA) lesions of the nucleus accumbens (N. Acc.). Both D-1 and D-2 receptor antagonists produced dose-dependent blockade of the supersensitive locomotor response at doses that did not depress baseline locomotor activity. The behavioral properties of these D-1 and D-2 receptor antagonists were further examined using a simple step-down motor task. Both antagonists produced catalepsy as evidenced by dose-dependent increases in step- down latency. These results indicate that drugs with distinct in vitro dopamine binding affinities cannot be distinguished on the basis of their ability to inhibit supersensitive locomotor activity or simple motor tasks in rats in vivo.

subject areas

  • Animals
  • Apomorphine
  • Benzazepines
  • Hydroxydopamines
  • Kinetics
  • Male
  • Motor Activity
  • Nucleus Accumbens
  • Oxidopamine
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Spiperone
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(86)90322-x

PubMed ID

  • 2946915
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Additional Document Info

start page

  • 1985

end page

  • 1993

volume

  • 39

issue

  • 21

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