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IgM-producing tumors in the BALB-c mouse: A model for B-cell maturation

Academic Article
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Overview

authors

  • Andersson, J.
  • Buxbaum, Joel
  • Citronbaum, R.
  • Douglas, S.
  • Forni, L.
  • Melchers, F.
  • Pernis, B.
  • Stott, D.

publication date

  • 1974

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Five adjuvant induced BALB/c tumors producing IgM-McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781-were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10-25-h stimulated normal B cells, 3469 cells resemble 20-35-h stimulated B cells, TEPC 183 cells resemble 45-65-h stimulated B cells, Y 5781 cells resemble 80-110-h stimulated B cells, and McPc 774 cells resemble 100-130-h stimulated B cells.

subject areas

  • Animals
  • B-Lymphocytes
  • Cytoplasm
  • Dactinomycin
  • Endoplasmic Reticulum
  • Fluorescent Antibody Technique
  • Fucose
  • Galactose
  • Histocytochemistry
  • Immunoglobulin M
  • Kinetics
  • Leucine
  • Lymphoma, Non-Hodgkin
  • Mannose
  • Mice
  • Mice, Inbred BALB C
  • Mitogens
  • Models, Biological
  • Neoplasms, Experimental
  • Tritium
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Identity

PubMed Central ID

  • PMC2139610

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.140.3.742

PubMed ID

  • 4606641
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Additional Document Info

start page

  • 742

end page

  • 763

volume

  • 140

issue

  • 3

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