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C-fos protein expression in the rat subfornical organ following osmotic stimulation

Academic Article
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Overview

authors

  • Giovannelli, L.
  • Bloom, Floyd

publication date

  • May 1992

journal

  • Neuroscience Letters  Journal

abstract

  • To examine the role of the subfornical organ (SFO) in the osmotic activation of hypothalamic neurons, the responses of the SFO to osmotic stimulation were evaluated by using c-Fos protein immunohistochemistry. Numerous c-Fos-immunoreactive nuclei were found in the SFO of rats injected i.p. with hypertonic saline solution as early as 30 min after stimulation, and the effect lasted up to 3 h. Only a few c-Fos-positive cells were detected in the SFO of rats injected with isotonic saline. However, electrolytic lesions of the SFO did not prevent the osmotic activation of the hypothalamic paraventricular and supraoptic nuclei. These data suggest that the SFO and the hypothalamic magnocellular nuclei are simultaneously but separately activated by osmotic stress.

subject areas

  • Animals
  • Cell Nucleus
  • Gene Expression Regulation, Neoplastic
  • Hypothalamus
  • Male
  • Osmolar Concentration
  • Proto-Oncogene Proteins c-fos
  • Rats
  • Rats, Sprague-Dawley
  • Subfornical Organ
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Research

keywords

  • C-FOS
  • HYPOTHALAMUS
  • NUCLEUS-TRACTUS-SOLITARIUS
  • OSMOTIC STRESS
  • PARAVENTRICULAR NUCLEUS
  • SUBFORNICAL ORGAN
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(92)90844-w

PubMed ID

  • 1407673
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Additional Document Info

start page

  • 1

end page

  • 6

volume

  • 139

issue

  • 1

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