Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Neuron-glia adhesion is inhibited by antibodies to neural determinants

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Grumet, M.
  • Rutishauser, U.
  • Edelman, Gerald

publication date

  • 1983

journal

  • Science  Journal

abstract

  • Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • Cell Adhesion
  • Cell Membrane
  • Cells, Cultured
  • Chick Embryo
  • Epitopes
  • Immunoglobulin Fab Fragments
  • Neuroglia
  • Neurons
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6194561

PubMed ID

  • 6194561
scroll to property group menus

Additional Document Info

start page

  • 60

end page

  • 62

volume

  • 222

issue

  • 4619

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support