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Neuron-glia adhesion is inhibited by antibodies to neural determinants

Academic Article
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Overview

authors

  • Grumet, M.
  • Rutishauser, U.
  • Edelman, Gerald

publication date

  • 1983

journal

  • Science  Journal

abstract

  • Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • Cell Adhesion
  • Cell Membrane
  • Cells, Cultured
  • Chick Embryo
  • Epitopes
  • Immunoglobulin Fab Fragments
  • Neuroglia
  • Neurons
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6194561

PubMed ID

  • 6194561
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Additional Document Info

start page

  • 60

end page

  • 62

volume

  • 222

issue

  • 4619

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