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Increased cns levels of apolipoprotein d in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders

Academic Article
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Overview

authors

  • Thomas, Elizabeth
  • Dean, B.
  • Pavey, G.
  • Sutcliffe, J. Gregor

publication date

  • March 2001

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. Here, we measured a significant decrease in the concentration of apoD in serum samples from schizophrenic patients. In contrast, apoD levels were significantly increased (92--287%) in dorsolateral prefrontal cortex (Brodmann's area 9) of schizophrenic and bipolar subjects. Elevated levels of apoD expression were also observed in the caudate of schizophrenic and bipolar subjects (68--89%). No differences in apoD immunoreactivity were detected in occipital cortex (Brodmann's area 18) in either group, or in the hippocampus, substantia nigra, or cerebellum of the schizophrenic group. The low serum concentrations of apoD observed in these patients supports recent hypotheses involving systemic insufficiencies in lipid metabolism/signaling in schizophrenia. Elevation of apoD expression selectively within central nervous system regions implicated in the pathology of these neuropsychiatric disorders suggests a focal compensatory response that neuroleptic drug regimens may augment.

subject areas

  • Adult
  • Analysis of Variance
  • Apolipoproteins
  • Apolipoproteins D
  • Bipolar Disorder
  • Blotting, Western
  • Brain
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia
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Identity

PubMed Central ID

  • PMC31180

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.071056198

PubMed ID

  • 11274430
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Additional Document Info

start page

  • 4066

end page

  • 4071

volume

  • 98

issue

  • 7

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