Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Structural characterization of a heterogeneous family of rat-brain messenger-rnas

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Tsou, A. P.
  • Lai, C.
  • Danielson, P.
  • Noonan, D. J.
  • Sutcliffe, J. Gregor

publication date

  • March 1986

journal

  • Molecular and Cellular Biology  Journal

abstract

  • A large heterogeneous family of RNAs derived from a single rat gene contains members that differ from each other at one or more of three positions. Their 5' ends are nested and transcription can begin at 22 or more sites covering 265 nucleotides. Many of the 5' ends are detectable only in brain RNAs, and even 5' ends common with other tissues appear with different absolute and relative abundances in brain RNA. The central portions of the RNAs are of two forms, differing only by the presence or absence of 17 nucleotides; these forms are probably produced by alternative splicing. Polyadenylation occurs at either of two sites. This complicated family of 88 RNAs encodes two novel putative proteins that differ at their C termini.

subject areas

  • Animals
  • Base Sequence
  • Brain Chemistry
  • Cloning, Molecular
  • DNA
  • Endonucleases
  • Kidney
  • Liver
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Weight
  • Organ Specificity
  • RNA, Messenger
  • Rats
  • Rats, Inbred Strains
  • Single-Strand Specific DNA and RNA Endonucleases
  • Species Specificity
scroll to property group menus

Identity

PubMed Central ID

  • PMC367577

International Standard Serial Number (ISSN)

  • 0270-7306

PubMed ID

  • 3022128
scroll to property group menus

Additional Document Info

start page

  • 768

end page

  • 778

volume

  • 6

issue

  • 3

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support