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Inferences, questions and possibilities in toll-like receptor signalling

Academic Article
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Overview

authors

  • Beutler, Bruce

publication date

  • July 2004

journal

  • Nature  Journal

abstract

  • The Toll-like receptors (TLRs) are the key proteins that allow mammals--whether immunologically naive or experienced--to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine.

subject areas

  • Animals
  • Autoimmunity
  • Humans
  • Immunity, Innate
  • Inflammation
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Sepsis
  • Signal Transduction
  • Toll-Like Receptors
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature02761

PubMed ID

  • 15241424
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Additional Document Info

start page

  • 257

end page

  • 263

volume

  • 430

issue

  • 6996

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