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Kinase consensus sequences: A breeding ground for crosstalk

Academic Article
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Overview

authors

  • Rust, H. L.
  • Thompson, Paul

publication date

  • September 2011

journal

  • ACS Chemical Biology  Journal

abstract

  • The best characterized examples of crosstalk between two or more different post-translational modifications (PTMs) occur with respect to histones. These examples demonstrate the critical roles that crosstalk plays in regulating cell signaling pathways. Recently, however, non-histone crosstalk has been observed between serine/threonine phosphorylation and the modification of arginine and lysine residues within kinase consensus sequences. Interestingly, many kinase consensus sequences contain critical arginine/lysine residues surrounding the substrate serine/threonine residue. Therefore, we hypothesize that non-histone crosstalk between serine/threonine phosphorylation and arginine/lysine modifications is a global mechanism for the modulation of cellular signaling. In this review, we discuss several recent examples of non-histone kinase consensus sequence crosstalk, as well as provide the biophysical basis for these observations. In addition, we predict likely examples of crosstalk between protein arginine methyltransferase 1 (PRMT1) and Akt and discuss the future implications of these findings.

subject areas

  • Amino Acids
  • Consensus Sequence
  • Humans
  • Phosphorylation
  • Protein Kinases
  • Signal Transduction
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Identity

PubMed Central ID

  • PMC3176959

International Standard Serial Number (ISSN)

  • 1554-8929

Digital Object Identifier (DOI)

  • 10.1021/cb200171d

PubMed ID

  • 21721511
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Additional Document Info

start page

  • 881

end page

  • 892

volume

  • 6

issue

  • 9

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